The effects of bisphosphonates on jaw bone remodeling, tissue properties, and extraction healing

被引：30

作者：

Allen, Matthew R. ^{[1
]}

机构：

[1] Indiana Univ Sch Med, Dept Anat & Cell Biol, Indianapolis, IN 46202 USA

来源：

ODONTOLOGY | 2011年 / 99卷 / 01期

关键词：

Bone turnover; Osteonecrosis of the jaw; Microdamage; Antiremodeling treatment; Necrosis; CORTICAL BONE; MICRODAMAGE ACCUMULATION; BIOMECHANICAL PROPERTIES; OSTEOCYTE APOPTOSIS; ALVEOLAR PROCESS; 1-YEAR TREATMENT; ZOLEDRONIC ACID; BEAGLE DOGS; OSTEONECROSIS; ALENDRONATE;

D O I：

10.1007/s10266-010-0153-0

中图分类号：

R78 [口腔科学];

学科分类号：

100302 [口腔临床医学];

摘要：

Bisphosphonate effects on the skeleton have been studied in the context of a broad range of disciplines, including endocrinology, orthopedics, oncology, and dentistry. The emergence of osteonecrosis of the jaw as a rare but serious side effect of bisphosphonate treatment has stimulated interest in understanding how this drug class affects the oral skeleton. This review focuses on recent work describing how bisphosphonates affect bone remodeling, tissue properties, and postsurgical healing in the oral cavity.

引用

页码：8 / 17

页数：10

共 74 条

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Antiremodeling agents influence osteoblast activity differently in modeling and remodeling sites of canine rib [J].

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CALCIFIED TISSUE INTERNATIONAL, 2006, 79 (04) :255-261

[5]

Compromised osseous healing of dental extraction sites in zoledronic acid-treated dogs [J].

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[6]

Alendronate reduces bone toughness of ribs without significantly increasing microdamage accumulation in dogs following 3 years of daily treatment [J].

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Mandible matrix necrosis in beagle dogs after 3 years of daily oral bisphosphonate treatment [J].

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[8]

Three years of alendronate treatment results in similar levels of vertebral microdamage as after one year of treatment [J].

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JOURNAL OF BONE AND MINERAL RESEARCH, 2007, 22 (11) :1759-1765

[9]

Alterations in canine vertebral bone turnover, microdamage accumulation, and biomechanical properties following 1-year treatment with clinical treatment doses of risedronate or alendronate [J].

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[10]

Greater magnitude of turnover suppression occurs earlier after treatment initiation with risedronate than alendronate [J].

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BONE, 2011, 49 (01) :128-132

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