Three years of alendronate treatment results in similar levels of vertebral microdamage as after one year of treatment

被引：94

作者：

Allen, Matthew R.

Burr, David B.

机构：

[1] Indiana Univ, Sch Med, Dept Anat & Cell Biol, Indianapolis, IN 46202 USA

[2] Indiana Univ, Sch Med, Dept Orthopaed Surg, Indianapolis, IN 46202 USA

[3] Indiana Univ Purdue Univ, Dept Biomed Engn, Indianapolis, IN 46202 USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2007年 / 22卷 / 11期

关键词：

bisphosphonates; remodeling; toughness; biomechanics; osteoporosis;

D O I：

10.1359/JBMR.070720

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Three years of daily alendronate treatment increases microdamage in vertebral bone but does not significantly increase it beyond levels of microdamage found after 1 yr of treatment. This suggests microdamage accumulation peaks during the early period of bisphosphonate treatment and does not continue to accumulate with longer periods of treatment.

引用

收藏

页码：1759 / 1765

页数：7

相关论文

共 26 条

[1] Alterations in canine vertebral bone turnover, microdamage accumulation, and biomechanical properties following 1-year treatment with clinical treatment doses of risedronate or alendronate [J].

Allen, Matthew R. ;

Iwata, Ken ;

Phipps, Roger ;

Burr, David B. .

BONE, 2006, 39 (04) :872-879

[2]

ALLEN MR, 2007, IN PRESS OSTEOPOROS

[3]

Allen MR., 2007, IBMS BoneKEy, V4, P49, DOI DOI 10.1138/20060248

[4] Intracortical remodeling in adult rat long bones after fatigue loading [J].

Bentolila, V ;

Boyce, TM ;

Fyhrie, DP ;

Drumb, R ;

Skerry, TM ;

Schaffler, MB .

BONE, 1998, 23 (03) :275-281

[5] Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures [J].

Black, DM ;

Cummings, SR ;

Karpf, DB ;

Cauley, JA ;

Thompson, DE ;

Nevitt, MC ;

Bauer, DC ;

Genant, HK ;

Haskell, WL ;

Marcus, R ;

Ott, SM ;

Torner, JC ;

Quandt, SA ;

Reiss, TF ;

Ensrud, KE .

LANCET, 1996, 348 (9041) :1535-1541

[6] Ten years' experience with alendronate for osteoporosis in postmenopausal women [J].

Bone, HG ;

Hosking, D ;

Devogelaer, J ;

Tucci, JR ;

Emkey, RD ;

Tonino, RP ;

Rodriguez-Portales, JA ;

Downs, RW ;

Gupta, J ;

Santora, AC ;

Liberman, UA .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (12) :1189-1199

[7] Bone microdamage acid skeletal fragility in osteoporotic and stress fractures [J].

Burr, DB ;

Forwood, MR ;

Fyhrie, DP ;

Martin, B ;

Schaffler, MB ;

Turner, CH .

JOURNAL OF BONE AND MINERAL RESEARCH, 1997, 12 (01) :6-15

[8] BONE REMODELING IN RESPONSE TO INVIVO FATIGUE MICRODAMAGE [J].

BURR, DB ;

MARTIN, RB ;

SCHAFFLER, MB ;

RADIN, EL .

JOURNAL OF BIOMECHANICS, 1985, 18 (03) :189-&

[9] VALIDITY OF THE BULK-STAINING TECHNIQUE TO SEPARATE ARTIFACTUAL FROM INVIVO BONE MICRODAMAGE [J].

BURR, DB ;

STAFFORD, T .

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 1990, (260) :305-308

[10] Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures - Results from the fracture intervention trial [J].

Cummings, SR ;

Black, DM ;

Thompson, DE ;

Applegate, WB ;

Barrett-Connor, E ;

Musliner, TA ;

Palermo, L ;

Prineas, R ;

Rubin, SM ;

Scott, JC ;

Vogt, T ;

Wallace, R ;

Yates, AJ ;

LaCroix, AZ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 280 (24) :2077-2082