Morphogenetic concepts of normal and abnormal growth in the human prostate

被引:31
作者
Bonkhoff, H [1 ]
Remberger, K [1 ]
机构
[1] Univ Saarland, Inst Pathol, D-66421 Homburg, Germany
关键词
morphogenesis; benign prostatic hyperplasia; prostate cancer;
D O I
10.1007/s004280050236
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Benign prostatic hyperplasia (BPH) and prostate cancer are multifactorial disease processes, involving a growing number of biochemical, genetic and epigenetic factors. Their pathogenesis, however, remains poorly understood. The present review examines current morphogenetic concepts of normal and abnormal growth in the human prostate. This includes the role of basal cells in organogenesis and cancerogenesis, the impact of cell-matrix interactions, and the importance of cellular heterogeneity in tumour progression and hormone-insensitive growth. Knowledge of morphogenesis and morphology is required in any scientific approach to BPH and prostate cancer.
引用
收藏
页码:195 / 202
页数:8
相关论文
共 75 条
[1]   MORPHOLOGIC AND ENDOCRINE ASPECTS OF PROSTATIC FUNCTION [J].
AUMULLER, G .
PROSTATE, 1983, 4 (02) :195-214
[2]   WIDESPREAD DISTRIBUTION OF NUCLEAR ANDROGEN RECEPTORS IN THE BASAL-CELL LAYER OF THE NORMAL AND HYPERPLASTIC HUMAN PROSTATE [J].
BONKHOFF, H ;
REMBERGER, K .
VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY, 1993, 422 (01) :35-38
[3]  
Bonkhoff H, 1996, PROSTATE, V29, P261, DOI 10.1002/(SICI)1097-0045(199610)29:4<261::AID-PROS7>3.0.CO
[4]  
2-E
[5]  
Bonkhoff H, 1996, PROSTATE, V28, P98
[6]   MULTIDIRECTIONAL DIFFERENTIATION IN THE NORMAL, HYPERPLASTIC, AND NEOPLASTIC HUMAN PROSTATE - SIMULTANEOUS DEMONSTRATION OF CELL-SPECIFIC EPITHELIAL MARKERS [J].
BONKHOFF, H ;
STEIN, U ;
REMBERGER, K .
HUMAN PATHOLOGY, 1994, 25 (01) :42-46
[7]   RELATION OF ENDOCRINE-PARACRINE CELLS TO CELL-PROLIFERATION IN NORMAL, HYPERPLASTIC, AND NEOPLASTIC HUMAN PROSTATE [J].
BONKHOFF, H ;
WERNERT, N ;
DHOM, G ;
REMBERGER, K .
PROSTATE, 1991, 19 (02) :91-98
[8]   ANDROGEN RECEPTOR STATUS IN ENDOCRINE-PARACRINE CELL-TYPES OF THE NORMAL, HYPERPLASTIC, AND NEOPLASTIC HUMAN PROSTATE [J].
BONKHOFF, H ;
STEIN, U ;
REMBERGER, K .
VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY, 1993, 423 (04) :291-294
[9]   ENDOCRINE-PARACRINE CELL-TYPES IN THE PROSTATE AND PROSTATIC ADENOCARCINOMA ARE POSTMITOTIC CELLS [J].
BONKHOFF, H ;
STEIN, U ;
REMBERGER, K .
HUMAN PATHOLOGY, 1995, 26 (02) :167-170
[10]  
Bonkhoff H, 1998, PROSTATE, V34, P251, DOI 10.1002/(SICI)1097-0045(19980301)34:4<251::AID-PROS2>3.0.CO