Morphogenetic concepts of normal and abnormal growth in the human prostate

被引：31

作者：

Bonkhoff, H ^{[1
]}

Remberger, K ^{[1
]}

机构：

[1] Univ Saarland, Inst Pathol, D-66421 Homburg, Germany

来源：

VIRCHOWS ARCHIV | 1998年 / 433卷 / 03期

关键词：

morphogenesis; benign prostatic hyperplasia; prostate cancer;

D O I：

10.1007/s004280050236

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Benign prostatic hyperplasia (BPH) and prostate cancer are multifactorial disease processes, involving a growing number of biochemical, genetic and epigenetic factors. Their pathogenesis, however, remains poorly understood. The present review examines current morphogenetic concepts of normal and abnormal growth in the human prostate. This includes the role of basal cells in organogenesis and cancerogenesis, the impact of cell-matrix interactions, and the importance of cellular heterogeneity in tumour progression and hormone-insensitive growth. Knowledge of morphogenesis and morphology is required in any scientific approach to BPH and prostate cancer.

引用

页码：195 / 202

页数：8

共 75 条

[11]

2-K

[12]

Bonkhoff H, 1996, EUR UROL, V30, P201

[13] DISTRIBUTION OF BASEMENT-MEMBRANES IN PRIMARY AND METASTATIC CARCINOMAS OF THE PROSTATE [J].