The role of microRNA and other non-coding RNA in the pathogenesis of chronic lymphocytic leukemia

被引：88

作者：

Calin, George A. ^{[1
]}

Pekarsky, Yuri ^{[1
]}

Croce, Carlo M. ^{[1
]}

机构：

[1] Ohio State Univ, Ctr Comprehens Canc, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

来源：

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2007年 / 20卷 / 03期

关键词：

microRNAs; BCL2; TCL1; microarray profiling; CLL;

D O I：

10.1016/j.beha.2007.02.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

New findings support the view that chronic lymphocytic leukemia (CLL) is a genetic disease in which the main alterations occur in a new class of genes named microRNAs (miRNAs). Cases with good prognostic features typically are characterized by miRNA down-regulation of genes miR-15a and miR-16-1, located at 13q 14.3. Both microRNAs negatively regulate BCL2 at a post-transcriptional level. On the other hand, in CLL cases that use unmutated immunoglobulin heavy-chain variable-region genes (IgV(H)) or have high-level expression of the 70-kD zeta-associated protein (ZAP-70) have high levels of TCLl due to low-level expression of miR-29 and miR- 18 1, which directly target this oncogene. Conceivably, these miRNAs might be used to target BCL2 or TCLl for therapy of this disease.

引用

页码：425 / 437

页数：13

共 63 条

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