Solid-phase synthesis of peptide aldehydes directly on acetal resin

被引：15

作者：

Yao, W ^{[1
]}

Xu, HY ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 13期

关键词：

D O I：

10.1016/S0040-4039(01)00230-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical strategy for solid-phase synthesis of peptide aldehydes has been developed employing a 10,11-dihydroxy-undecanoic acid (DHUA) functionalized resin. High loading levels are obtained for amino aldehydes as their respective acetals. After classical Fmoc SPPS, treatment of the derivatized resin with 95% TFA/H2O affords peptide aldehydes in high yield and purity. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2549 / 2552

页数：4

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