Phospho-regulation of β-catenin adhesion and signaling functions

被引：206

作者：

Daugherty, Rebecca Leadem ^{[1
]}

Gottardi, Cara J.

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA

[2] Northwestern Univ, Feinberg Sch Med, Lurie Canc Ctr, Chicago, IL 60611 USA

[3] Northwestern Univ, Feinberg Sch Med, Integrated Grad Program Life Sci, Chicago, IL 60611 USA

来源：

PHYSIOLOGY | 2007年 / 22卷 / 05期

关键词：

D O I：

10.1152/physiol.00020.2007

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

beta-Catenin plays a critical structural role in cadherin- based adhesions and is also an essential co-activator of Wnt-mediated gene expression. The degree to which beta-catenin participates in these two functions is dictated by the availability of beta-catenin binding partners, and an emerging theme is that these binding interactions are regulated by phosphorylation. Inputs from various cell-signaling events can therefore impact beta-catenin function, which may be necessary for the finely tuned adhesive and signaling responses required for tissue morphogenesis.

引用

页码：303 / 309

页数：7

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