Essential role of BCL9-2 in the switch between β-catenin's adhesive and transcriptional functions

被引：268

作者：

Brembeck, FH

Schwarz-Romond, T

Bakkers, J

Wilhelm, S

Hammerschmidt, M

Birchmeier, W ^{[1
]}

机构：

[1] Max Delbruck Ctr Mol Med, D-13092 Berlin, Germany

[2] Max Planck Inst Immunbiol, D-79108 Freiburg, Germany

来源：

GENES & DEVELOPMENT | 2004年 / 18卷 / 18期

关键词：

BCL9/legless; alpha-catenin; Wnt8; tyrosine phosphorylation; epithelial-mesenchymal transition; mesoderm patterning;

D O I：

10.1101/gad.317604

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

beta-Catenin controls both cadherin-mediated cell adhesion and activation of Wnt target genes. We demonstrate here that the beta-catenin-binding protein BCL9-2, a homolog of the human proto-oncogene product BCL9, induces epithelial-mesenchymal transitions of nontransformed cells and increases beta-catenin-dependent transcription. RNA interference of BCL9-2 in carcinoma cells induces an epithelial phenotype and translocates beta-catenin from the nucleus to the cell membrane. The switch between beta-catenin's adhesive and transcriptional functions is modulated by phosphorylation of Tyr 142 of beta-catenin, which favors BCL9-2 binding and precludes interaction with alpha-catenin. During zebrafish embryogenesis, BCL9-2 acts in the Wnt8-signaling pathway and regulates mesoderm patterning.

引用

收藏

页码：2225 / 2230

页数：6

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