A piezoelectric biomimetic sensor for aminopyrine with a molecularly imprinted polymer coating

被引:32
作者
Tan, YG [1 ]
Nie, LH [1 ]
Yao, SZ [1 ]
机构
[1] Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Peoples R China
关键词
D O I
10.1039/b100693m
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A molecularly imprinted polymer for aminopyrine was synthesized using methacrylic acid as functional monomer. The polymer was employed as the recognition element of a piezoelectric bulk acoustic wave biomimetic sensor for aminopyrine. Influencing factors were investigated in detail and optimized. This sensor exhibited high selectivity and sensitivity to aminopyrine. The response range of the sensor was between 5.0 x 10(-8) and 1.0 x 10(-4) M with a detection limit of 2.5 x 10(-8) M in the aqueous system. Scatchard analysis with UV spectrophotometry showed that the same class of binding sites was formed in the molecularly imprinted polymer in the studied concentration range, and the dissociation constant and the apparent maximum number of these binding sites were estimated to be 2.29 mM and 165.0 mu mol g(-1) dry polymer, respectively. Impedance analysis was employed to verify the imprinting effect and lack of variation in the viscoelasticity of the polymer coating during detection.
引用
收藏
页码:664 / 668
页数:5
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