A novel method for high-throughput reduction of compounds through automated sequential injection into a continuous-flow microfluidic reactor

被引：24

作者：

Jones, R

Gödörházy, L

Szalay, D

Gerencsér, J

Dormán, G

Ürge, L

Darvas, F

机构：

[1] Thales Nanotechnol Inc, H-1031 Budapest, Hungary

[2] ComGenex Inc, H-1031 Budapest, Hungary

来源：

QSAR & COMBINATORIAL SCIENCE | 2005年 / 24卷 / 06期

关键词：

continuous-flow microfluidic reactor; high-throughput heterogeneous hydrogenation;

D O I：

10.1002/qsar.200540006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A high-throughput system for heterogeneous hydrogenation through the integration of a microfluidic reactor into an automated injector-fraction collector robot is described. The reduction of a small nitro compound library is used to demonstrate the high-throughput capability of the system and the results are compared to those of a batch reactor.

引用

收藏

页码：722 / 727

页数：6

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