Fluvoxamine-methadone interaction

被引：19

作者：

Alderman, CP ^{[1
]}

Frith, PA ^{[1
]}

机构：

[1] Repatriat Gen Hosp, Daw Pk, SA 5041, Australia

来源：

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY | 1999年 / 33卷 / 01期

关键词：

drug interaction; fluvoxamine; methadone;

D O I：

10.1046/j.1440-1614.1999.00522.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: The aim of this paper is to report a case of symptomatic methadone toxicity associated with fluvoxamine treatment. Clinical picture: A 28-year-old woman was admitted to hospital with severe hypoxaemia and hypercapnia indicating hypoventilation. Medication prior to admission had been stable and included methadone 70 mg daily and diazepam 2 mg twice daily. Three weeks before admission she had commenced treatment with fluvoxamine. Treatment: Methadone was decreased to 50 mg daily and diazepam was tapered to zero. Outcome: The serum methadone concentration decreased and oxygenation improved considerably. Conclusions: Clinicians should be aware of the potential for a significant drug interaction between fluvoxamine and methadone.

引用

页码：99 / 101

页数：3

共 12 条

[1] Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors [J].