Modification of polyethersulfone hemodialysis membrane by blending citric acid grafted polyurethane and its anticoagulant activity

被引：138

作者：

Li, Lulu ^{[1
]}

Cheng, Chong ^{[1
]}

Xiang, Tao ^{[1
]}

Tang, Min ^{[1
]}

Zhao, Weifeng ^{[1
]}

Sun, Shudong ^{[1
]}

Zhao, Changsheng ^{[1
,2
]}

机构：

[1] Sichuan Univ, Coll Polymer Sci & Engn, State Key Lab Polymer Mat Engn, Chengdu 610065, Peoples R China

[2] Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China

来源：

JOURNAL OF MEMBRANE SCIENCE | 2012年 / 405卷

基金：

中国国家自然科学基金;

关键词：

Polyethersulfone membrane; Citric acid grafted polyurethane; Blood compatibility; Cytocompatibility; VITRO BLOOD COMPATIBILITY; CONTACT-ANGLE TECHNIQUE; PLASMA GLOW-DISCHARGE; BOVINE SERUM-ALBUMIN; SURFACE MODIFICATION; PROTEIN-ADSORPTION; PLATELET-ADHESION; IN-VITRO; ULTRAFILTRATION MEMBRANES; HEPARIN CONJUGATE;

D O I：

10.1016/j.memsci.2012.03.015

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Citric acid, a widely used anticoagulant, was grafted onto polyurethane through a two-step solution polymerization. The novel synthesized polymer can be directly blended with polyethersulfone (PES) to prepare membranes. The modified membranes showed lower protein (bovine serum albumin, BSA; bovine serum fibrinogen, BFG) adsorption and suppressed platelet adhesion. Due to the binding of calcium ions in blood, the modified membranes effectively prolonged the activated partial thromboplastin time (APTT), prothrombin time (PT), plasma recalcification time (PRT) and the whole blood clotting time (WBCT). Furthermore, the modified membranes showed good cytocompatibility, and the surfaces promoted hepatocyte adhesion and proliferation compared to pure PES membrane. These results indicated that the surface modification by blending citric acid grafted polyurethane provided practical application of the membranes with good biocompatibility, especially the anticoagulant property; and the membranes could be used in blood purification fields, such as hemodialysis and bioaritificial liver assist devices. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：261 / 274

页数：14