Population imaging of ongoing neuronal activity in the visual cortex of awake rats

被引：300

作者：

Greenberg, David S. ^{[1
,2
]}

Houweling, Arthur R. ^{[3
,4
]}

Kerr, Jason N. D. ^{[1
,5
]}

机构：

[1] Max Planck Inst Biol Cybernet, Network Imaging Grp, D-72076 Tubingen, Germany

[2] Max Planck Inst Med Res, Dept Cell Physiol, D-69120 Heidelberg, Germany

[3] Erasmus MC, Dept Neurosci, NL-3000 CA Rotterdam, Netherlands

[4] Humboldt Univ, Bernstein Ctr Computat Neurosci, D-10115 Berlin, Germany

[5] Max Planck Inst Med Res, Dept Biomed Opt, D-69120 Heidelberg, Germany

来源：

NATURE NEUROSCIENCE | 2008年 / 11卷 / 07期

关键词：

D O I：

10.1038/nn.2140

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It is unclear how the complex spatiotemporal organization of ongoing cortical neuronal activity recorded in anesthetized animals relates to the awake animal. We therefore used two-photon population calcium imaging in awake and subsequently anesthetized rats to follow action potential firing in populations of neurons across brain states, and examined how single neurons contributed to population activity. Firing rates and spike bursting in awake rats were higher, and pair-wise correlations were lower, compared with anesthetized rats. Anesthesia modulated population-wide synchronization and the relationship between firing rate and correlation. Overall, brain activity during wakefulness cannot be inferred using anesthesia.

引用

页码：749 / 751

页数：3

共 15 条

[1] Correlation between neural spike trains increases with firing rate [J].