Complementary detection of prostate-specific antigen using ln2O3 nanowires and carbon nanotubes

被引:328
作者
Li, C
Curreli, M
Lin, H
Lei, B
Ishikawa, FN
Datar, R
Cote, RJ
Thompson, ME
Zhou, CW [1 ]
机构
[1] Univ So Calif, Dept Elect Engn, Los Angeles, CA 90089 USA
[2] Univ So Calif, Dept Chem, Los Angeles, CA 90089 USA
[3] Univ So Calif, Dept Pathol, Los Angeles, CA 90089 USA
关键词
D O I
10.1021/ja053761g
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
We report complementary detection of prostate-specific antigen (PSA) using n-type In2O3 nanowires and p-type carbon nanotubes. Our innovation involves developing an approach to covalently attach antibodies to In2O3 NW surfaces via the onsite surface synthesis of phosphonic acid-succinylimide ester. Electronic measurements under dry conditions revealed complementary response for In2O3 NW and SWNT devices after the binding of PSA. Real-time detection in solution has also been demonstrated for PSA down to 5 ng/mL, a benchmark concentration significant for clinical diagnosis of prostate cancer, which is the most frequently diagnosed cancer. Copyright © 2005 American Chemical Society.
引用
收藏
页码:12484 / 12485
页数:2
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