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A tour of structural genomics

被引：117
作者：
Brenner, SE [1 ]
机构：
[1] Univ Calif Berkeley, Dept Plant & Microbial Biol, Berkeley, CA 94720 USA
来源：
NATURE REVIEWS GENETICS | 2001年 / 2卷 / 10期
关键词：
D O I：
10.1038/35093574
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Structural genomics projects aim to provide an experimental or computational three-dimensional model structure for all of the tractable macromolecules that are encoded by complete genomes. To this end, pilot centres worldwide are now exploring the feasibility of large-scale structure determination. Their experimental structures and computational models are expected to yield insight into the molecular function and mechanism of thousands of proteins. The pervasiveness of this information is likely to change the use of structure in molecular biology and biochemistry.
引用
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页码：801 / 809
页数：9
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