Morphogen gradient interpretation

被引：534

作者：

Gurdon, JB

Bourillot, PY

机构：

[1] Wellcome CRC Inst, Cambridge CB2 1QR, England

[2] Univ Cambridge, Dept Zool, Cambridge, England

来源：

NATURE | 2001年 / 413卷 / 6858期

关键词：

D O I：

10.1038/35101500

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A morphogen gradient is an important concept in developmental biology, because it describes a mechanism by which the emission of a signal from one part of an embryo can determine the location, differentiation and fate of many surrounding cells. The value of this idea has been clear for over half a century, but only recently have experimental systems and methods of analysis progressed to the point where we begin to understand how a cell can sense and respond to tiny changes in minute concentrations of extracellular signalling factors.

引用

页码：797 / 803

页数：7

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