The role of substance abuse in HIV disease progression: Reconciling differences from laboratory and epidemiologic investigations

被引:109
作者
Kapadia, F
Vlahov, D
Donahoe, RM
Friedland, G
机构
[1] New York Acad Med, Ctr Urban Epidemiol Studies, New York, NY 10029 USA
[2] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA
[3] Yale Univ, Yale New Haven Hosp, Sch Med, AIDS Program, New Haven, CT 06504 USA
关键词
D O I
10.1086/433175
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
From the onset of the HIV/AIDS epidemic, the use of licit and illicit drugs has been investigated for its potential impact on HIV disease progression. Findings from a large number of laboratory-based studies indicate that drug abuse may exacerbate HIV disease progression; however, epidemiological studies have shown mixed results. This article presents a review of findings from both laboratory-based and epidemiologic investigations. In addition, we provide a careful evaluation of methodological strengths and limitations inherent to both study designs in order to provide a more nuanced understanding of how these findings may complement one another.
引用
收藏
页码:1027 / 1034
页数:8
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共 93 条
[61]  
PHILLIPS AN, 1992, J ACQ IMMUN DEF SYND, V5, P148
[62]   Differences in HIV disease progression by injection drug use and by sex in the era of highly active antiretroviral therapy [J].
Poundstone, KE ;
Chaisson, RE ;
Moore, RD .
AIDS, 2001, 15 (09) :1115-1123
[63]   Comparison of progression and non-progression in injecting drug users and homosexual men with documented dates of HIV-1 seroconversion [J].
Prins, M ;
Veugelers, PJ .
AIDS, 1997, 11 (05) :621-631
[64]   Pre-AIDS mortality and its association with HIV disease progression in haemophilic men, injecting drug users and homosexual men [J].
Prins, M ;
Sabin, CA ;
Lee, CA ;
Devereux, H ;
Coutinho, RA .
AIDS, 2000, 14 (12) :1829-1837
[65]   Pre-AIDS mortality from natural causes associated with HIV disease progression: evidence from the European Seroconverter Study among injecting drug users [J].
Prins, M ;
Aguado, IH ;
Brettle, RP ;
Robertson, JR ;
Broers, B ;
Carre, N ;
Goldberg, DJ ;
Zangerle, R ;
Coutinho, RA ;
vandenHoek, A .
AIDS, 1997, 11 (14) :1747-1756
[66]   Abrupt or precipitated withdrawal from morphine induces immunosuppression [J].
Rahim, TR ;
Adler, MW ;
Meissler, JJ ;
Cowan, A ;
Rogers, TJ ;
Geller, EB ;
Eisenstein, TK .
JOURNAL OF NEUROIMMUNOLOGY, 2002, 127 (1-2) :88-95
[67]  
Rainey PM, 2000, J ACQ IMMUN DEF SYND, V24, P241
[68]   The pharmacokinetics of methadone following co-administration with a lamivudine/zidovudine combination tablet in opiate-dependent subjects [J].
Rainey, PM ;
Friedland, GH ;
Snidow, JW ;
McCance-Katz, EF ;
Mitchell, SM ;
Andrews, L ;
Lane, B ;
Jatlow, P .
AMERICAN JOURNAL ON ADDICTIONS, 2002, 11 (01) :66-74
[69]   Evaluation of possible effects of continued drug use on HIV progression among women [J].
Rompalo, AM ;
Shah, N ;
Margolick, JB ;
Farzadegan, H ;
Arnsten, J ;
Schuman, P ;
Rich, JD ;
Gardner, LI ;
Smith, DK ;
Vlahov, D .
INTERNATIONAL JOURNAL OF STD & AIDS, 2004, 15 (05) :322-327
[70]   HIV-1 INFECTION AND INTRAVENOUS DRUG-USE - LONGITUDINAL NEUROPSYCHOLOGICAL EVALUATION OF ASYMPTOMATIC SUBJECTS [J].
SELNES, OA ;
MCARTHUR, JC ;
ROYAL, W ;
UPDIKE, ML ;
NANCESPROSON, T ;
CONCHA, M ;
GORDON, B ;
SOLOMON, L ;
VLAHOV, D .
NEUROLOGY, 1992, 42 (10) :1924-1930