Phase-transfer-catalyzed asymmetric Darzens reaction using a new chiral ammonium salt

被引：48

作者：

Arai, S ^{[1
]}

Tokumaru, K ^{[1
]}

Aoyama, T ^{[1
]}

机构：

[1] Nagoya City Univ, Grad Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 09期

关键词：

Darzens reaction; phase-transfer; asymmetric synthesis;

D O I：

10.1016/j.tetlet.2004.01.009

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Catalytic asymmetric Darzens reaction of haloamides is described. A new and easily-prepared bis-ammonium salt derived from BINOL acts as an effective phase-transfer catalyst and efficiently promotes the reaction to give the desired epoxides under quite mild conditions with up to 70% ee. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1845 / 1848

页数：4

共 25 条

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