Upregulation of B7-H1 expression is associated with macrophage infiltration in hepatocellular carcinomas

被引：133

作者：

Chen, Jie ^{[1
]}

Li, Guosheng ^{[1
]}

Meng, Hong ^{[2
]}

Fan, Yuchen ^{[3
]}

Song, Yonghong ^{[4
]}

Wang, Shurong ^{[4
]}

Zhu, Faliang ^{[1
]}

Guo, Chun ^{[1
]}

Zhang, Lining ^{[1
]}

Shi, Yongyu ^{[1
]}

机构：

[1] Shandong Univ, Sch Med, Inst Immunol, Jinan 250012, Peoples R China

[2] Shandong Acad Med Sci, Inst Basic Med, Shandong, Peoples R China

[3] Shandong Univ, Dept Hepatol, Qilu Hosp, Shandong, Peoples R China

[4] Shandong Blood Ctr, Shandong, Peoples R China

来源：

CANCER IMMUNOLOGY IMMUNOTHERAPY | 2012年 / 61卷 / 01期

关键词：

B7-H1; CD274; Hepatocellular carcinoma; PD-L1; Tumor-associated macrophages; TUBULAR EPITHELIAL-CELLS; POSTOPERATIVE RECURRENCE; POOR-PROGNOSIS; T-CELLS; PD-L1; CANCER; INFLAMMATION; GAMMA; PROGRESSION; APOPTOSIS;

D O I：

10.1007/s00262-011-1094-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The overexpression of B7-H1 in hepatocellular carcinoma (HCC) mediates HCC immune escape and obstructs the immunotherapy based on tumor-specific CD8+ T cells. Tumor-associated macrophages (TAM) are a major component of cancer-related inflammation and play a central role in tumor promotion. To classify the mechanism underlying the overexpression of B7-H1 in HCC, we examined B7-H1 expression and TAM infiltration in 63 cases of human HCC samples using immunohistochemistry method and found that B7-H1 overexpression was associated with TAM infiltration in HCC tissues. Furthermore, B7-H1 expression was upregulated at both mRNA level and protein level in HCC cells (BEL-7402 and SMMC-7721) cocultured with macrophages in a transwell system. The upregulation of B7-H1 expression induced by macrophage was inhibited by blocking NF-kappa B or STAT3 signal pathways. These results suggest that overexpression of B7-H1 in HCC may be induced by inflammatory microenvironment involving macrophages and imply that anti-inflammation therapy might be preventive for immune escape and assistant for immunotherapy of HCC.

引用

页码：101 / 108

页数：8

共 37 条

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