Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

被引：2535

作者：

Colotta, Francesco ^{[2
]}

Allavena, Paola ^{[1
]}

Sica, Antonio ^{[1
,3
]}

Garlanda, Cecilia ^{[1
]}

Mantovani, Alberto ^{[1
,4
]}

机构：

[1] Ist Clin Humanitas IRCCS, Dept Immunol & Inflammat, I-20089 Milan, Italy

[2] Nerviano Med Sci, I-20014 Milan, Italy

[3] Univ Piemonte Orientale, Inst Pathol, I-28100 Novara, Italy

[4] Univ Milan, Dept Translat Med, I-20121 Milan, Italy

来源：

CARCINOGENESIS | 2009年 / 30卷 / 07期

关键词：

TUMOR-ASSOCIATED MACROPHAGES; NF-KAPPA-B; INDUCED CYTIDINE DEAMINASE; NECROSIS-FACTOR-ALPHA; HELICOBACTER-PYLORI INFECTION; CELL-CYCLE PROGRESSION; NITRIC-OXIDE; OXIDATIVE STRESS; SUPPRESSOR-CELLS; MYELOID CELLS;

D O I：

10.1093/carcin/bgp127

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Inflammatory conditions in selected organs increase the risk of cancer. An inflammatory component is present also in the microenvironment of tumors that are not epidemiologically related to inflammation. Recent studies have begun to unravel molecular pathways linking inflammation and cancer. In the tumor microenvironment, smoldering inflammation contributes to proliferation and survival of malignant cells, angiogenesis, metastasis, subversion of adaptive immunity, reduced response to hormones and chemotherapeutic agents. Recent data suggest that an additional mechanism involved in cancer-related inflammation (CRI) is induction of genetic instability by inflammatory mediators, leading to accumulation of random genetic alterations in cancer cells. In a seminal contribution, Hanahan and Weinberg [(2000) Cell, 100, 57-70] identified the six hallmarks of cancer. We surmise that CRI represents the seventh hallmark.

引用

页码：1073 / 1081

页数：9

共 188 条

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Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: Role of bone marrow-derived myelomonocytic cells [J].