The use of dominant-negative mutations to elucidate signal transduction pathways in lymphocytes

被引：15

作者：

Perlmutter, RM ^{[1
]}

AlberolaIla, J ^{[1
]}

机构：

[1] UNIV WASHINGTON, HOWARD HUGHES MED INST,DEPT IMMUNOL,DEPT BIOCHEM, DEPT MED MED GENET, SEATTLE, WA 98195 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1996年 / 8卷 / 02期

关键词：

D O I：

10.1016/S0952-7915(96)80069-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent publications document an exponential increase in the use of dominant-negative mutations as tools for the experimental dissection of lymphocyte signaling pathways. This approach may be the only one available for in vitro analysis of cell lines. Moreover, when implemented in transgenic animals, dominant-negative mutations boast certain advantages over gene-targeting strategies.

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收藏

页码：285 / 290

页数：6

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