Dopamine-loaded chitosan nanoparticles: formulation and analytical characterization

被引：66

作者：

De Giglio, Elvira ^{[1
]}

Trapani, Adriana ^{[2
]}

Cafagna, Damiana ^{[1
]}

Sabbatini, Luigia ^{[1
]}

Cometa, Stefania ^{[3
]}

机构：

[1] Univ Bari, Dept Chem, I-70125 Bari, Italy

[2] Univ Bari, Dept Pharmaceut Chem, Sch Pharm, I-70125 Bari, Italy

[3] Univ Pisa, Dept Chem & Ind Chem, I-56126 Pisa, Italy

来源：

ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2011年 / 400卷 / 07期

关键词：

Chitosan; Nanoparticles; Dopamine; QCM-D; FT-IR; XPS; TRIPOLYPHOSPHATE; FILMS;

D O I：

10.1007/s00216-011-4962-y

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

The formulation and characterization of dopamine (DA)-loaded chitosan nanoparticles (CSNPs) are described as preliminary steps for the development of potential DA carrier systems intended for Parkinson's disease treatment. For this purpose, CSNPs were firstly produced and, afterwards, they were incubated in a DA aqueous solution to promote neurotransmitter loading. The characterization of the resulting nanoparticles started with Fourier transform infrared spectroscopy analysis to ascertain the presence of DA in the nanocarrier, whereas X-ray photoelectron spectroscopy analysis provided evidence of the localization of DA on the nanoparticle surface. A quartz crystal microbalance with dissipation monitoring (QCM-D) was then exploited to investigate both swelling of CSNPs and interaction of DA with CSNPs. In particular, the QCM-D revealed that this interaction is fast and so this allows a stable nanostructured system to be obtained.

引用

页码：1997 / 2002

页数：6

共 19 条

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