Mixed-backbone oligonucleotides as second-generation antisense agents with reduced phosphorothioate-related side effects

被引：38

作者：

Zhou, WQ ^{[1
]}

Agrawal, S ^{[1
]}

机构：

[1] Hybridon Inc, Milford, MA 01757 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(98)00591-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Mixed-backbone oligonucleotides containing alternative phosphorothioate and phosphodiester linkages in the 2'-O-methylribonucleosides segment show increased affinity with complementary targets, increased stability towards nucleases in vitro and in vivo, and reduced phosphorothioate-related prolongation of partial thromboplastin time compared to phosphorothioate oligodeoxynucleotides, thereby providing antisense agents with reduced side effects. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：3269 / 3274

页数：6

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