Endometrial Carcinomas: A Review Emphasizing Overlapping and Distinctive Morphological and Immunohistochemical Features

被引：73

作者：

Bartosch, Carla ^{[3
]}

Lopes, Jose Manuel ^{[3
,4
,5
]}

Oliva, Esther ^{[1
,2
]}

机构：

[1] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

[3] Univ Porto IPATIMUP, Ctr Hosp S Joao, Oporto, Portugal

[4] Univ Porto IPATIMUP, Fac Med, Oporto, Portugal

[5] Univ Porto IPATIMUP, Inst Mol Pathol & Immunol, Oporto, Portugal

来源：

ADVANCES IN ANATOMIC PATHOLOGY | 2011年 / 18卷 / 06期

关键词：

uterus; endometrium; endometrial carcinoma; endometrioid; serous; clear cell; dedifferentiated; malignant mixed mullerian; lynch-related; FEMALE GENITAL-TRACT; CLEAR-CELL CARCINOMA; NONPOLYPOSIS COLORECTAL-CANCER; UTERINE SEROUS CARCINOMA; E-CADHERIN EXPRESSION; SMOOTH-MUSCLE TUMORS; METASTATIC BREAST-CARCINOMA; SYNCHRONOUS PRIMARY CANCERS; MULLERIAN MESODERMAL TUMOR; BETA-CATENIN EXPRESSION;

D O I：

10.1097/PAP.0b013e318234ab18

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

This review focuses on the most common diagnostic pitfalls and helpful morphologic and immunohistochemical markers in the differential diagnosis between the different subtypes of endometrial carcinomas, including: (1) endometrioid versus serous glandular carcinoma, (2) papillary endometrioid (not otherwise specified, villoglandular and nonvillous variants) versus serous carcinoma, (3) endometrioid carcinoma with spindle cells, hyalinization, and heterologous components versus malignant mixed mullerian tumor, (4) high-grade endometrioid versus serous carcinoma, (5) high-grade endometrioid carcinoma versus dedifferentiated or undifferentiated carcinoma, (6) endometrioid carcinoma with clear cells versus clear cell carcinoma, (7) clear cell versus serous carcinoma, (8) undifferentiated versus neuroendocrine carcinoma, (9) carcinoma of mixed cell types versus carcinoma with ambiguous features or variant morphology, (10) Lynch syndrome-related endometrial carcinomas, (11) high-grade or undifferentiated carcinoma versus nonepithelial uterine tumors. As carcinomas in the endometrium are not always primary, this review also discusses the differential diagnosis between endometrial carcinomas and other gynecological malignancies such as endocervical (glandular) and ovarian/peritoneal serous carcinoma, as well as with extra-gynecologic metastases (mainly breast and colon).

引用

页码：415 / 437

页数：23

共 257 条

[31]

BARTOSCH C, 2010, MED ONCOL

[32] BREAST-CARCINOMA METASTATIC TO UTERINE LEIOMYOMA [J].

BEATTIE, GJ ;

DUNCAN, AJ ;

PATERSON, AJ ;

WILLIAMS, ARW ;

GEIRSSON, RT .

GYNECOLOGIC ONCOLOGY, 1993, 51 (02) :255-257

[33] Hurthle cell carcinoma metastatic to uterus [J].

Benbassat, CA ;

Mechlis-Frish, S ;

Morgenstein, S .

THYROID, 2005, 15 (11) :1309-1310

[34] Clinicopathological characteristics and long-term outcome in patients with distant metastases from differentiated thyroid cancer [J].

Benbassat, Carlos A. ;

Mechlis-Frish, Sara ;

Hirsch, Dania .

WORLD JOURNAL OF SURGERY, 2006, 30 (06) :1088-1095

[35]

Biscuola M, 2011, MODERN PATHOL, V24, p237A

[36] THE SIGNIFICANCE OF EPITHELIAL DIFFERENTIATION IN MIXED MESODERMAL TUMORS OF THE UTERUS - A CLINICOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY [J].

BITTERMAN, P ;

CHUN, B ;

KURMAN, RJ .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1990, 14 (04) :317-328

[37] Pathologic features of endometrial carcinoma associated with HNPCC - A comparison with sporadic endometrial carcinoma [J].

Broaddus, RR ;

Lynch, HT ;

Chen, LM ;

Daniels, MS ;

Conrad, P ;

Munsell, MF ;

White, KG ;

Luthra, R ;

Lu, KH .

CANCER, 2006, 106 (01) :87-94

[38]

Brown RW, 1997, AM J CLIN PATHOL, V107, P12

[39]

BUR M, 1993, MODERN PATHOL, V6, P469

[40] PTEN mutations in endometrial carcinomas: A molecular and clinicopathologic analysis of 38 cases [J].

Bussaglia, E ;

del Rio, E ;

Matias-Guiu, X ;

Prat, J .

HUMAN PATHOLOGY, 2000, 31 (03) :312-317

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