Amyloid-β Associated Volume Loss Occurs Only in the Presence of Phospho-Tau

被引：102

作者：

Desikan, Rahul S. ^{[1
]}

McEvoy, Linda K. ^{[1
]}

Thompson, Wesley K. ^{[2
]}

Holland, Dominic ^{[3
]}

Roddey, J. Cooper ^{[3
]}

Blennow, Kaj ^{[4
]}

Aisen, Paul S. ^{[3
]}

Brewer, James B. ^{[1
,3
]}

Hyman, Bradley T. ^{[5
]}

Dale, Anders M. ^{[1
,3
]}

机构：

[1] Univ Calif San Diego, Dept Radiol, La Jolla, CA 92037 USA

[2] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92037 USA

[3] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92037 USA

[4] Goteburg Univ, Sahlgrenska Acad, Clin Neurochem Lab, Gothenburg, Sweden

[5] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA

来源：

ANNALS OF NEUROLOGY | 2011年 / 70卷 / 04期

基金：

美国国家卫生研究院; 瑞典研究理事会;

关键词：

DISEASE MOUSE MODEL; ALZHEIMERS-DISEASE; ELDERLY SUBJECTS; A-BETA(42);

D O I：

10.1002/ana.22509

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The relationship between neurodegeneration and the 2 hallmark proteins of Alzheimer's disease, amyloid-beta (A beta) and tau, is still unclear. Here, we examined 286 nondemented participants (107 cognitively normal older adults and 179 memory impaired individuals) who underwent longitudinal magnetic resonance (MR) imaging and lumbar puncture. Using mixed effects models, we investigated the relationship between longitudinal entorhinal cortex atrophy rate, cerebrospinal fluid (CSF) p-tau(181p) and CSF A beta(1-42). We found a significant relationship between elevated entorhinal cortex atrophy rate and decreased CSF A beta(1-42) only with elevated CSF p-tau(181p). Our findings indicate that neurodegeneration-associated volume loss occurs only in the presence of phospho-tau in humans at risk for dementia. ANN NEUROL 2011;70:657-661

引用

页码：657 / 661

页数：5

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