Synthesis and in vitro leishmanicidal activity of 2-(5-nitro-2-furyl) and 2-(5-nitro-2-thienyl)-5-substituted-1,3,4-thiadiazoles

被引：60

作者：

Foroumadi, A

Pournourmohammadi, S

Soltani, F

Asgharian-Rezaee, M

Dabiri, S

Kharazmi, A

Shafiee, A ^{[1
]}

机构：

[1] Univ Tehran Med Sci, Pharmaceut Sci Res Ctr, Tehran 14174, Iran

[2] LICA Pharmaceut, DK-2100 Copenhagen, Denmark

[3] Kerman Univ Med Sci, Fac Pharm, Kerman 76351, Iran

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 08期

关键词：

1,3,4-thiadiazole; nitrofuran; nitrothiophene; leishmanicidal activity;

D O I：

10.1016/j.bmcl.2005.02.073

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 2-(5-nitro-2-furyl) and 2-(5-nitro-2-thienyl)-5-substituted-1,3,4-thiadiazoles (5a-d and 6a-j) were synthesized and evaluated against Leishmania major promastigotes using H-3-thymidine incorporation. Most of the compounds showed activity better than the reference drug sodium stibogluconate (Pentostam). The most active compound was 6c (IC50 = 0-1 mu M). (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1983 / 1985

页数：3

共 15 条

[1]

Ali A, 2002, ETHIOPIAN MED J, V40, P37

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