ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma

被引：117

作者：

Su, GH

Bansal, R

Murphy, KM

Montgomery, E

Yeo, CJ

Hruban, RH

Kern, SE

机构：

[1] Johns Hopkins Med Inst, Dept Oncol, Baltimore, MD 21231 USA

[2] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21231 USA

[3] Johns Hopkins Med Inst, Dept Surg, Baltimore, MD 21231 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2001年 / 98卷 / 06期

关键词：

D O I：

10.1073/pnas.051484398

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

DPC4 is known to mediate signals initiated by type beta transforming growth factor (TCF beta) as well as by other TGF beta superfamily ligands such as activin and BMP (bone morphogenic proteins), but mutational surveys of such non-TGF beta receptors have been negative to date. Here we describe the gene structure and novel somatic mutations of the activin type I receptor, ACVR1B, in pancreatic cancer. ACVR1B has not been described previously as a mutated tumor-suppressor gene.

引用

页码：3254 / 3257

页数：4

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