Noise in solid-state nanopores

被引：305

作者：

Smeets, R. M. M. ^{[1
]}

Keyser, U. F. ^{[1
,2
]}

Dekker, N. H. ^{[1
]}

Dekker, C. ^{[1
]}

机构：

[1] Delft Univ Technol, Kavil Inst Nanosci, NL-2628 CJ Delft, Netherlands

[2] Univ Leipzig, Inst Expt Phys 1, D-04103 Leipzig, Germany

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2008年 / 105卷 / 02期

关键词：

D O I：

10.1073/pnas.0705349105

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We study ionic current fluctuations in solid-state nanopores over a wide frequency range and present a complete description of the noise characteristics. At low frequencies (f less than or similar to 100 Hz) we observe 1/f-type of noise. We analyze this low-frequency noise at different salt concentrations and find that the noise power remarkably scales linearly with the inverse number of charge carriers, in agreement with Hooge's relation. We find a Hooge parameter alpha = (1.1 +/- 0.1) x 10(-4). in the high-frequency regime (f less than or similar to 1 kHz), we can model the increase in current power spectral density with frequency through a calculation of the Johnson noise. Finally, we use these results to compute the signal-to-noise ratio for DNA translocation for different salt concentrations and nanopore diameters, yielding the parameters for optimal detection efficiency.

引用

页码：417 / 421

页数：5

共 23 条

[1] EVALUATION OF THE RATE CONSTANTS OF SUGAR-TRANSPORT THROUGH MALTOPORIN (LAMB) OF ESCHERICHIA-COLI FROM THE SUGAR-INDUCED CURRENT NOISE [J].

ANDERSEN, C ;

JORDY, M ;

BENZ, R .

JOURNAL OF GENERAL PHYSIOLOGY, 1995, 105 (03) :385-401

[2] Probing sugar translocation through maltoporin at the single channel level [J].

Bezrukov, SM ;

Kullman, L ;

Winterhalter, M .

FEBS LETTERS, 2000, 476 (03) :224-228

[3] CURRENT NOISE REVEALS PROTONATION KINETICS AND NUMBER OF IONIZABLE SITES IN AN OPEN PROTEIN ION CHANNEL [J].

BEZRUKOV, SM ;

KASIANOWICZ, JJ .

PHYSICAL REVIEW LETTERS, 1993, 70 (15) :2352-2355

[4] Examining noise sources at the single-molecule level:: 1/f noise of an open maltoporin channel [J].

Bezrukov, SM ;

Winterhalter, M .

PHYSICAL REVIEW LETTERS, 2000, 85 (01) :202-205

[5] Atomic layer deposition to fine-tune the surface properties and diameters of fabricated nanopores [J].

Chen, P ;

Mitsui, T ;

Farmer, DB ;

Golovchenko, J ;

Gordon, RG ;

Branton, D .

NANO LETTERS, 2004, 4 (07) :1333-1337

[6] Solid-state nanopores [J].

Dekker, Cees .

NATURE NANOTECHNOLOGY, 2007, 2 (04) :209-215

[7] EXPERIMENTAL STUDIES ON 1-F NOISE [J].

HOOGE, FN ;

KLEINPENNING, TGM ;

VANDAMME, LKJ .

REPORTS ON PROGRESS IN PHYSICS, 1981, 44 (05) :479-532

[8] 1/F NOISE IS NO SURFACE EFFECT [J].

HOOGE, FN .

PHYSICS LETTERS A, 1969, A 29 (03) :139-&

[9] Characterization of individual polynucleotide molecules using a membrane channel [J].

Kasianowicz, JJ ;

Brandin, E ;

Branton, D ;

Deamer, DW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (24) :13770-13773

[10] Fabrication and characterization of nanopore-based electrodes with radii down to 2 nm [J].

Krapf, D ;

Wu, MY ;

Smeets, RMM ;

Zandbergen, HW ;

Dekker, C ;

Lemay, SG .

NANO LETTERS, 2006, 6 (01) :105-109

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