Immunity to K1 killer toxin: Internal TOK1 blockade

被引：25

作者：

Sesti, F

Shih, TM

Nikolaeva, N

Goldstein, SAN

机构：

[1] Yale Univ, Sch Med, Boyer Ctr Mol Med, Dept Pediat, New Haven, CT 06536 USA

[2] Yale Univ, Sch Med, Boyer Ctr Mol Med, Dept Cellular & Mol Physiol, New Haven, CT 06536 USA

来源：

CELL | 2001年 / 105卷 / 05期

关键词：

D O I：

10.1016/S0092-8674(01)00376-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

K1 killer strains of Saccharomyces cerevisiae harbor RNA viruses that mediate secretion of K1, a protein toxin that kills virus-free cells. Recently, external K1 toxin was shown to directly activate TOK1 channels in the plasma membranes of sensitive yeast cells, leading to excess potassium flux and cell death. Here, a mechanism by which killer cells resist their own toxin is shown: internal toxin inhibits TOK1 channels and suppresses activation by external toxin.

引用

收藏

页码：637 / 644

页数：8

相关论文

共 38 条

[1] A molecular target for viral killer toxin: TOK1 potassium channels [J].

Ahmed, A ;

Sesti, F ;

Ilan, N ;

Shih, TM ;

Sturley, SL ;

Goldstein, SAN .

CELL, 1999, 99 (03) :283-291

[2]

ALALDROOS K, 1978, CAN J MICROBIOL, V24, P228

[3] FUNCTIONAL EXPRESSION OF A PROBABLE ARABIDOPSIS-THALIANA POTASSIUM CHANNEL IN SACCHAROMYCES-CEREVISIAE [J].

ANDERSON, JA ;

HUPRIKAR, SS ;

KOCHIAN, LV ;

LUCAS, WJ ;

GABER, RF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (09) :3736-3740

[4] YEAST KRE GENES PROVIDE EVIDENCE FOR A PATHWAY OF CELL-WALL BETA-GLUCAN ASSEMBLY [J].

BOONE, C ;

SOMMER, SS ;

HENSEL, A ;

BUSSEY, H .

JOURNAL OF CELL BIOLOGY, 1990, 110 (05) :1833-1843

[5]

BOONE C, 1986, CELL, V46, P105, DOI 10.1016/0092-8674(86)90864-0

[6] SEQUENCE OF THE PREPROTOXIN DSRNA GENE OF TYPE-I KILLER YEAST - MULTIPLE PROCESSING EVENTS PRODUCE A 2-COMPONENT TOXIN [J].

BOSTIAN, KA ;

ELLIOTT, Q ;

BUSSEY, H ;

BURN, V ;

SMITH, A ;

TIPPER, DJ .

CELL, 1984, 36 (03) :741-751

[7] TRANSLATIONAL ANALYSIS OF THE KILLER-ASSOCIATED VIRUS-LIKE PARTICLE DSRNA GENOME OF S CEREVISIAE - M-DSRNA ENCODES TOXIN [J].

BOSTIAN, KA ;

HOPPER, JE ;

ROGERS, DT ;

TIPPER, DJ .

CELL, 1980, 19 (02) :403-414

[8]

BUSSEMAKERS MJG, 1991, PROGR UROLOGIE S, V1, P5

[9] PHYSIOLOGY OF KILLER FACTOR IN YEAST [J].

BUSSEY, H .

ADVANCES IN MICROBIAL PHYSIOLOGY, 1981, 22 :93-122

[10] SECRETION OF SACCHAROMYCES-CEREVISIAE KILLER TOXIN - PROCESSING OF THE GLYCOSYLATED PRECURSOR [J].

BUSSEY, H ;

SAVILLE, D ;

GREENE, D ;

TIPPER, DJ ;

BOSTIAN, KA .

MOLECULAR AND CELLULAR BIOLOGY, 1983, 3 (08) :1362-1370

← 1 2 3 4 →