Immunity to K1 killer toxin: Internal TOK1 blockade

被引：25

作者：

Sesti, F

Shih, TM

Nikolaeva, N

Goldstein, SAN

机构：

[1] Yale Univ, Sch Med, Boyer Ctr Mol Med, Dept Pediat, New Haven, CT 06536 USA

[2] Yale Univ, Sch Med, Boyer Ctr Mol Med, Dept Cellular & Mol Physiol, New Haven, CT 06536 USA

来源：

CELL | 2001年 / 105卷 / 05期

关键词：

D O I：

10.1016/S0092-8674(01)00376-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

K1 killer strains of Saccharomyces cerevisiae harbor RNA viruses that mediate secretion of K1, a protein toxin that kills virus-free cells. Recently, external K1 toxin was shown to directly activate TOK1 channels in the plasma membranes of sensitive yeast cells, leading to excess potassium flux and cell death. Here, a mechanism by which killer cells resist their own toxin is shown: internal toxin inhibits TOK1 channels and suppresses activation by external toxin.

引用

页码：637 / 644

页数：8

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