Expression pattern of NOGO and NgR genes during human development

被引：23

作者：

Al Halabiah, H

Delezoide, AL

Cardona, A

Moalic, JM

Simonneau, M

机构：

[1] Hop Robert Debre, INSERM, E9935, AP HP, F-75019 Paris, France

[2] Inst Pasteur, Histotechnol & Pathol Unit, F-75724 Paris, France

来源：

GENE EXPRESSION PATTERNS | 2005年 / 5卷 / 04期

关键词：

Nogo; NgR; in situ hybridizatiom; human brain development; human tooth development;

D O I：

10.1016/j.modgep.2004.10.010

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Nogo protein has been identified as the component of central nervous system (CNS) myelin that limits axonal regeneration. We investigated the expression of the genes encoding Nogo and its receptor, NgR, between weeks eight and 23 of human embryonic development, by quantitative radioactive in situ hybridization. At 8 weeks, we detected NOGO and NgR transcripts in developing neuronal and non-neuronal structures. We focused on two different structures: the brain and the dental germs. During this period of development, NOGO and NgR transcripts colocalized in the cortical and ventricular zones of the brain, with expression strongest for these two genes in the postmitotic cells of the cortical plate. In developing dental germs, NgR was more strongly expressed than NOGO at 16 and 21 weeks. NOGO and NgR were expressed in zones of epithelium-mesenchyme interaction, which induce the differentiation of ameloblasts/odontoblasts. These genes were expressed most strongly in differentiated cells. (c) 2004 Elsevier B.V. All rights reserved.

引用

页码：561 / 568

页数：8

共 37 条

[1] A new role for Nogo as a regulator of vascular remodeling [J].