High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma

被引：540

作者：

Linnemann, Carsten ^{[1
]}

van Buuren, Marit M. ^{[1
]}

Bies, Laura ^{[1
]}

Verdegaal, Els M. E. ^{[2
]}

Schotte, Remko ^{[3
]}

Calis, Jorg J. A. ^{[1
]}

Behjati, Sam ^{[4
]}

Velds, Arno ^{[5
]}

Hilkmann, Henk ^{[6
]}

el Atmioui, Dris ^{[6
]}

Visser, Marten ^{[2
]}

Stratton, Michael R. ^{[4
]}

Haanen, John B. A. G. ^{[1
,7
]}

Spits, Hergen ^{[3
]}

van der Burg, Sjoerd H. ^{[2
]}

Schumacher, Ton N. M. ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Immunol, NL-1066 CX Amsterdam, Netherlands

[2] Leiden Univ, Med Ctr, Dept Clin Oncol, Leiden, Netherlands

[3] AIMM Therapeut BV, Amsterdam, Netherlands

[4] Wellcome Trust Res Labs, Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton, England

[5] Netherlands Canc Inst, Cent Genom Facil, Amsterdam, Netherlands

[6] Netherlands Canc Inst, Peptide Synth Facil, Amsterdam, Netherlands

[7] Netherlands Canc Inst, Div Med Oncol, Amsterdam, Netherlands

来源：

NATURE MEDICINE | 2015年 / 21卷 / 01期

基金：

英国惠康基金;

关键词：

CD4+T CELLS; B-CELLS; TUMOR; PATIENT; IDENTIFICATION; REACTIVITY; GENES;

D O I：

10.1038/nm.3773

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tumor-specific neo-antigens that arise as a consequence of mutations(1,2) are thought to be important for the therapeutic efficacy of cancer immunotherapies(3-5). Accumulating evidence suggests that neo-antigens may be commonly recognized by intratumoral CD8(+) T cells(3-7), but it is unclear whether neoantigen-specific CD4(+) T cells also frequently reside within human tumors. In view of the accepted role of tumor-specific CD4(+) T-cell responses in tumor control(8-10), we addressed whether neo-antigen-specific CD4(+) T-cell reactivity is a common property in human melanoma.

引用

页码：81 / 85

页数：5

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