Checking two steps

被引：32

作者：

Kastan, MB ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Hematol Oncol, Memphis, TN 38105 USA

来源：

NATURE | 2001年 / 410卷 / 6830期

关键词：

D O I：

10.1038/35071218

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

When their DNA is damaged, cells temporarily stop multiplying to prevent the build-up of mutations. Two types of delay triggered by ionizing radiation appear to have common molecular starting points.

引用

页码：766 / 767

页数：2

共 11 条

[1] Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome [J].

Bell, DW ;

Varley, JM ;

Szydlo, TE ;

Kang, DH ;

Wahrer, DCR ;

Shannon, KE ;

Lubratovich, M ;

Verselis, SJ ;

Isselbacher, KJ ;

Fraumeni, JF ;

Birch, JM ;

Li, FP ;

Garber, JE ;

Haber, DA .

SCIENCE, 1999, 286 (5449) :2528-2531

[2] A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage [J].

Brown, AL ;

Lee, CH ;

Schwarz, JK ;

Mitiku, N ;

Piwnica-Worms, H ;

Chung, JH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (07) :3745-3750

[3] WAF1, A POTENTIAL MEDIATOR OF P53 TUMOR SUPPRESSION [J].

ELDEIRY, WS ;

TOKINO, T ;

VELCULESCU, VE ;

LEVY, DB ;

PARSONS, R ;

TRENT, JM ;

LIN, D ;

MERCER, WE ;

KINZLER, KW ;

VOGELSTEIN, B .

CELL, 1993, 75 (04) :817-825

[4] The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis [J].

Falck, J ;

Mailand, N ;

Syljuåsen, RG ;

Bartek, J ;

Lukas, J .

NATURE, 2001, 410 (6830) :842-847

[5]

HARPER JW, 1993, CELL, V75, P805

[6] DNA damage-induced activation of p53 by the checkpoint kinase Chk2 [J].

Hirao, A ;

Kong, YY ;

Matsuoka, S ;

Wakeham, A ;

Ruland, J ;

Yoshida, H ;

Liu, D ;

Elledge, SJ ;

Mak, TW .

SCIENCE, 2000, 287 (5459) :1824-1827

[7] The many substrates and functions of ATM [J].

Kastan, MB ;

Lim, DS .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2000, 1 (03) :179-186

[8] ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway [J].

Lim, DS ;

Kim, ST ;

Xu, B ;

Maser, RS ;

Lin, JY ;

Petrini, JHJ ;

Kastan, MB .

NATURE, 2000, 404 (6778) :613-+

[9] Rapid destruction of human Cdc25A in response to DNA damage [J].

Mailand, N ;

Falck, J ;

Lukas, C ;

Syljuåsen, RG ;

Welcker, M ;

Bartek, J ;

Lukas, L .

SCIENCE, 2000, 288 (5470) :1425-1429

[10] Linkage of ATM to cell cycle regulation by the Chk2 protein kinase [J].

Matsuoka, S ;

Huang, MX ;

Elledge, SJ .

SCIENCE, 1998, 282 (5395) :1893-1897

← 1 2 →