Methylprednisolone attenuates interferon-beta induced expression of HLA-DR on monocytes

被引:8
作者
Crockard, AD [1 ]
Treacy, MT [1 ]
Droogan, AG [1 ]
Hawkins, SA [1 ]
机构
[1] QUEENS UNIV BELFAST,ROYAL VICTORIA HOSP,DEPT NEUROL,BELFAST BT12 6BN,ANTRIM,NORTH IRELAND
关键词
HLA-DR; interferon-beta; methylprednisolone; monocytes; multiple sclerosis;
D O I
10.1016/S0165-5728(96)00100-2
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The effect of methylprednisolone on constitutive and interferon-beta (IFN-beta) induced HLA-DR expression on monocytes from multiple sclerosis (MS) patients was investigated. Constitutive HLA-DR expression was reduced by 50% following a single dose (500 mg) of intravenous methylprednisolone (IVMP). Stimulation with natural IFN-beta, in vitro, resulted in a 20 fold increase in HLA-DR expression. Following IVMP, IFN-beta inducible HLA-DR levels were reduced (non-significantly) by 20-30%. Experiments in which monocytes from normal subjects and MS patients were pre-treated in vitro with methylprednisolone prior to IFN-beta stimulation revealed that induction of HLA-DR was significantly inhibited; in contrast, IFN-beta induced HLA-DR expression was not down-regulated following subsequent in vitro treatment with methylprednisolone. These findings suggest that the immunomodulatory effects of IVMP could be attenuated in MS patients receiving regular IFN-beta therapy.
引用
收藏
页码:29 / 35
页数:7
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