Methylprednisolone attenuates interferon-beta induced expression of HLA-DR on monocytes

被引：8

作者：

Crockard, AD ^{[1
]}

Treacy, MT ^{[1
]}

Droogan, AG ^{[1
]}

Hawkins, SA ^{[1
]}

机构：

[1] QUEENS UNIV BELFAST,ROYAL VICTORIA HOSP,DEPT NEUROL,BELFAST BT12 6BN,ANTRIM,NORTH IRELAND

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1996年 / 70卷 / 01期

关键词：

HLA-DR; interferon-beta; methylprednisolone; monocytes; multiple sclerosis;

D O I：

10.1016/S0165-5728(96)00100-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effect of methylprednisolone on constitutive and interferon-beta (IFN-beta) induced HLA-DR expression on monocytes from multiple sclerosis (MS) patients was investigated. Constitutive HLA-DR expression was reduced by 50% following a single dose (500 mg) of intravenous methylprednisolone (IVMP). Stimulation with natural IFN-beta, in vitro, resulted in a 20 fold increase in HLA-DR expression. Following IVMP, IFN-beta inducible HLA-DR levels were reduced (non-significantly) by 20-30%. Experiments in which monocytes from normal subjects and MS patients were pre-treated in vitro with methylprednisolone prior to IFN-beta stimulation revealed that induction of HLA-DR was significantly inhibited; in contrast, IFN-beta induced HLA-DR expression was not down-regulated following subsequent in vitro treatment with methylprednisolone. These findings suggest that the immunomodulatory effects of IVMP could be attenuated in MS patients receiving regular IFN-beta therapy.

引用

页码：29 / 35

页数：7

共 29 条

[11] INTERFERON-BETA DOWN-REGULATES INTERFERON-GAMMA-INDUCED CLASS-II MHC MOLECULE EXPRESSION AND MORPHOLOGICAL-CHANGES IN PRIMARY CULTURES OF HUMAN BRAIN MICROVESSEL ENDOTHELIAL-CELLS [J].

HUYNH, HK ;

OGER, J ;

DOROVINIZIS, K .

JOURNAL OF NEUROIMMUNOLOGY, 1995, 60 (1-2) :63-73

[12] THE EFFECT OF METHYLPREDNISOLONE ON MONOCYTE EICOSANOID PRODUCTION IN PATIENTS WITH MULTIPLE-SCLEROSIS [J].

KIRK, PF ;

WILLIAMS, JD ;

PETERSEN, MM ;

COMPSTON, DAS .

JOURNAL OF NEUROLOGY, 1994, 241 (07) :427-431

[13] IMMUNOSUPPRESSION BY GLUCOCORTICOIDS - INHIBITION OF PRODUCTION OF MULTIPLE LYMPHOKINES BY INVIVO ADMINISTRATION OF DEXAMETHASONE [J].

KUNICKA, JE ;

TALLE, MA ;

DENHARDT, GH ;

BROWN, M ;

PRINCE, LA ;

GOLDSTEIN, G .

CELLULAR IMMUNOLOGY, 1993, 149 (01) :39-49

[14]

LING PD, 1985, J IMMUNOL, V135, P1857

[15]

LIVINGSTON DH, 1994, ARCH SURG-CHICAGO, V129, P172

[16] GLUCOCORTICOIDS DOWN-REGULATE DENDRITIC CELL-FUNCTION IN-VITRO AND IN-VIVO [J].

MOSER, M ;

DESMEDT, T ;

SORNASSE, T ;

TIELEMANS, F ;

CHENTOUFI, AA ;

MURAILLE, E ;

VANMECHELEN, C ;

URBAIN, J ;

LEO, O .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1995, 25 (10) :2818-2824

[17] THE DALE-E-MCFARLIN-MEMORIAL-LECTURE - THE IMMUNOLOGY OF THE MULTIPLE-SCLEROSIS LESION [J].

RAINE, CS .

ANNALS OF NEUROLOGY, 1994, 36 :S61-S72

[18] MONOCYTES IN ACTIVE MULTIPLE-SCLEROSIS - INTACT REGULATION OF HLA-DR DENSITY INVITRO DESPITE DECREASED HLA-DR DENSITY INVIVO [J].

RANSOHOFF, RM ;

TUOHY, VK ;

BARNA, BP ;

RUDICK, RA .

JOURNAL OF NEUROIMMUNOLOGY, 1992, 37 (03) :169-176

[19]

SACKSTEIN R, 1995, J INVEST MED, V43, P68

[20] EFFECT OF CORTICOSTEROIDS, CYCLOSPORINE-A, AND METHOTREXATE ON CYTOKINE RELEASE FROM MONOCYTES AND T-CELL SUBSETS [J].

SCHMIDT, J ;

FLEISSNER, S ;

HEIMANNWEITSCHAT, I ;

LINDSTAEDT, R ;

POMBERG, B ;

WERNER, U ;

SZELENYI, I .

IMMUNOPHARMACOLOGY, 1994, 27 (03) :173-179

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