Effects of the Combination Treatment of Raloxifene and Alendronate on the Biomechanical Properties of Vertebral Bone

被引：15

作者：

Diab, Tamim ^{[1
,2
,3
]}

Wang, Jason ^{[2
,3
]}

Reinwald, Susan ^{[1
]}

Guldberg, Robert E. ^{[2
,3
]}

Burr, David B. ^{[1
,4
]}

机构：

[1] Indiana Univ Sch Med, Dept Anat & Cell Biol, Indianapolis, IN 46202 USA

[2] Georgia Inst Technol, Parker H Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USA

[3] Georgia Inst Technol, George W Woodruff Sch Mech Engn, Atlanta, GA 30332 USA

[4] Indiana Univ Purdue Univ, Dept Biomed Engn, Indianapolis, IN 46202 USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2011年 / 26卷 / 02期

基金：

美国国家科学基金会;

关键词：

RALOXIFENE; ALENDRONATE; BIOMECHANICAL PROPERTIES; FRACTURE; DENSITY; MICRODAMAGE ACCUMULATION; POSTMENOPAUSAL WOMEN; FRACTURE RISK; DENSITY; TURNOVER; BISPHOSPHONATES; RISEDRONATE; REDUCTION; AGE;

D O I：

10.1002/jbmr.197

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Raloxifene (RAL) and alendronate (ALN) improve the biomechanical properties of bone by different mechanisms. The goal here was to investigate the effects of combination treatment of RAL and ALN on the biomechanical properties of vertebral bone. Six-month-old Sprague-Dawley rats (n = 80) were randomized into five experimental groups (sham, OVX, OVX + RAL, OVX + ALN, and OVX + RAL + ALN; n 16/group). Following euthanization, structural and derived material biomechanical properties of vertebral bodies were assessed. Density and dynamic histomorphometric measurements were made on cancellous bone. The results demonstrate that the structural biomechanical properties of vertebral bone are improved with the combination treatment. Stiffness and ultimate load of the OVX + RAL and OVX + ALN groups were significantly lower than those of sham animals, but the combination treatment with RAL + ALN was not significantly different from sham. Furthermore, the OVX + RAL + ALN group was the only agent-treated group in which the ultimate load was significantly higher than that in OVX animals (p<.05). Cancellous bone fractional volume (BV/TVcanc) and bone mineral density (aBMD) also were improved with the combination treatment. BV/TVcanc of the OVX + RAL + ALN group was 6.7% and 8.7% greater than that of the OVX + RAL (p<.05) and OVX + ALN (p<.05) groups, respectively. Areal BMD of the OVX + RAL or OVX + ALN groups was not significantly different from that in OVX animals, but the value in animals undergoing combination treatment was significantly higher than that in OVX or OVX + RAL animals alone and not significantly different from that in sham-operated animals. Turnover rates of both the RAL + ALN and ALN alone groups were lower than in the RAL-treated alone group (p<.05). We conclude that the combination treatment of raloxifene and alendronate has beneficial effects on bone volume, resulting in improvement in the structural properties of vertebral bone. (C) 2011 American Society for Bone and Mineral Research.

引用

页码：270 / 276

页数：7

共 31 条

[1]

Bisphosphonates alter trabecular bone collagen cross-linking and isomerization in beagle dog vertebra [J].

Allen, M. R. ;

Gineyts, E. ;

Leeming, D. J. ;

Burr, D. B. ;

Delmas, P. D. .

OSTEOPOROSIS INTERNATIONAL, 2008, 19 (03) :329-337

[2]

Changes in vertebral strength-density and energy absorption-density relationships following bisphosphonate treatment in beagle dogs [J].

Allen, M. R. ;

Burr, D. B. .

OSTEOPOROSIS INTERNATIONAL, 2008, 19 (01) :95-99

[3]

Three years of alendronate treatment results in similar levels of vertebral microdamage as after one year of treatment [J].

Allen, Matthew R. ;

Burr, David B. .

JOURNAL OF BONE AND MINERAL RESEARCH, 2007, 22 (11) :1759-1765

[4]

Raloxifene enhances material- level mechanical properties of femoral cortical and trabecular bone [J].

Allen, Matthew R. ;

Hogan, Harry A. ;

Hobbs, Wesley A. ;

Koivuniemi, Andrew S. ;

Koivuniemi, Mark C. ;

Burr, David B. .

ENDOCRINOLOGY, 2007, 148 (08) :3908-3913

[5]

Raloxifene enhances vertebral mechanical properties independent of bone density [J].

Allen, Matthew R. ;

Iwata, Ken ;

Sato, Masahiko ;

Burr, David B. .

BONE, 2006, 39 (05) :1130-1135

[6]

Alterations in canine vertebral bone turnover, microdamage accumulation, and biomechanical properties following 1-year treatment with clinical treatment doses of risedronate or alendronate [J].

Allen, Matthew R. ;

Iwata, Ken ;

Phipps, Roger ;

Burr, David B. .

BONE, 2006, 39 (04) :872-879

[7]

Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures [J].

Black, DM ;

Cummings, SR ;

Karpf, DB ;

Cauley, JA ;

Thompson, DE ;

Nevitt, MC ;

Bauer, DC ;

Genant, HK ;

Haskell, WL ;

Marcus, R ;

Ott, SM ;

Torner, JC ;

Quandt, SA ;

Reiss, TF ;

Ensrud, KE .

LANCET, 1996, 348 (9041) :1535-1541

[8]

BOYCE RW, 1995, J BONE MINER RES, V10, P211

[9]

Automatic segmentation of cortical and trabecular compartments based on a dual threshold technique for in vivo micro-CT bone analysis [J].

Buie, Helen R. ;

Campbell, Graeme M. ;

Klinck, R. Joshua ;

MacNeil, Joshua A. ;

Boyd, Steven K. .

BONE, 2007, 41 (04) :505-515

[10]

Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugs [J].

Cummings, SR ;

Karpf, DB ;

Harris, F ;

Genant, HK ;

Ensrud, K ;

LaCroix, AZ ;

Black, DM .

AMERICAN JOURNAL OF MEDICINE, 2002, 112 (04) :281-289

← 1 2 3 4 →