cagA gene and protein status among Iranian Helicobacter pylori strains

被引：39

作者：

Talebkhan, Yeganeh ^{[1
]}

Mohammadi, Marjan ^{[1
]}

Mohagheghi, Mohammad Ali ^{[2
]}

Vaziri, Hamid Reza ^{[3
]}

Hosseini, Mahmoud Eshagh ^{[4
]}

Mohajerani, Nazanin ^{[1
]}

Oghalaei, Akbar ^{[1
]}

Esmaeili, Maryam ^{[1
]}

Zamaninia, Leili ^{[1
]}

机构：

[1] Pasteur Inst Iran, Biotechnol Res Ctr, Tehran 13164, Iran

[2] Univ Tehran Med Sci, Canc Res Ctr, Tehran, Iran

[3] Mofarrah Hosp, Endoscopy Unit, Tehran, Iran

[4] Amiralam Hosp, Dept Gastroenterol, Tehran, Iran

来源：

DIGESTIVE DISEASES AND SCIENCES | 2008年 / 53卷 / 04期

关键词：

cagA; genotype; Iran; Helicobacter pylori; western blotting;

D O I：

10.1007/s10620-007-9978-y

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The wide geographic genetic diversity of Helicobacter pylori (Hp) and, in particular, the varying prevalence of cagA in different countries has been documented repeatedly. This study was designed to determine the frequency of cagA in Iranian Hp strains by means of genotyping and assessment of host antibodies. Helicobacter pylori strains from 235 patients, including 174 non-ulcer dyspepsia, 25 peptic ulcer and 36 gastric cancer patients, were studied. The frequencies of the 5', middle and 3' terminal regions of the cagA gene were 90.6, 57.6, 89%, respectively, with no correlation to the clinical outcomes. Antibodies against the CagA protein were present in 90.7% of patients. Multiple biopsy sampling in 97 cases revealed multiple infection in 16.5% of the patients. Sequencing of the seven variants of the 3' end of the cagA gene revealed no clustering and the distribution of the Iranian strains among those of other countries. Our results from the genotyping and serology analyses confirm that the majority of Iranian Hp strains are cagA-positive.

引用

页码：925 / 932

页数：8

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