Fighting bacterial infections-Future treatment options

被引：138

作者：

Fernebro, Jenny ^{[1
]}

机构：

[1] Swedish Res Council, S-10138 Stockholm, Sweden

来源：

DRUG RESISTANCE UPDATES | 2011年 / 14卷 / 02期

关键词：

Antibiotics; Resistance; Antimicrobial peptide; Antivirulence; Bacteriophage; Beta-lactamase inhibitor; Efflux pump inhibitor; Therapeutic antibody; Vaccine; RESISTANT STAPHYLOCOCCUS-AUREUS; SMALL-MOLECULE INHIBITORS; ANTHRAX LETHAL FACTOR; BETA-LACTAMASE INHIBITOR; CENTRAL VENOUS CATHETERS; HOST-DEFENSE PEPTIDES; IN-VITRO ACTIVITY; HUMAN MONOCLONAL-ANTIBODIES; ESCHERICHIA-COLI O157-H7; PHAGE LYTIC ENZYME;

D O I：

10.1016/j.drup.2011.02.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This review summarizes ongoing research aimed at finding novel drugs as alternatives to traditional antibiotics. Anti-virulence approaches, phage therapy and therapeutic antibodies are strategies that may yield drugs with high specificity and narrow spectra. Several candidates are currently being evaluated in clinical trials, mostly for topical applications, but so far, none have been approved for market authorization. Candidates based on antimicrobial peptides (natural, semisynthetic and synthetic) are also being tested in clinical trials, mostly for the topical treatment of chronic infections. An alternative to the development of new antibiotics is to find potentiators of traditional antibiotics; in this respect, beta-lactamase inhibitors are already in clinical use. Novel variants are under investigation as well as efflux pump inhibitors. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：125 / 139

页数：15

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