RNAIII-inhibiting-peptide-loaded in vivo Polymethylmethacrylate prevents in vivo Staphylococcus aureus biofilm formation

被引：43

作者：

Anguita-Alonso, Paloma

Giacometti, Andrea

Cirioni, Oscar

Ghiselli, Roberto

Orlando, Fiorenza

Saba, Vittorio

Scalise, Giorgio

Sevo, Milica

Tuzova, Marina

Patel, Robin

Balaban, Naomi

机构：

[1] Div Infect Dis, Coll Med, Mayo Clin, Rochester, MN USA

[2] Univ Politecn Marche, Inst Infect Dis & Publ Hlth, Ancona, Italy

[3] Univ Politecn Marche, IRRCS, INRCA, Dept Gen Surg, Ancona, Italy

[4] IRRCS, INRCA, Res Dept, Expt Anim Models Aging Units, Ancona, Italy

[5] Tufts Univ, Sch Vet, North Grafton, MA USA

[6] Coll Med, Mayo Clin, Div Clin Microbiol, Rochester, MN USA

[7] Boston Univ, Boston, MA 02215 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 07期

关键词：

D O I：

10.1128/AAC.00580-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Staphylococci, common orthopedic pathogens, form antibiotic-resistant biofilms. Polymethylmethacrylate (PMMA) beads loaded with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rats and shown to prevent methicillin-resistant Staphylococcus aureus infection. RIP release was bimodal, typical of previously-tested antibiotics. These results suggest that RIP-PMMA warrants further evaluation for management of orthopedic infections caused by staphylococci.

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收藏

页码：2594 / 2596

页数：3

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