The rising tide of early-onset colorectal cancer: a comprehensive review of epidemiology, clinical features, biology, risk factors, prevention, and early detection

被引:731
作者
Patel, Swati G. [1 ,2 ]
Karlitz, Jordan J. [3 ]
Yen, Timothy [1 ]
Lieu, Christopher H. [1 ]
Boland, C. Richard [4 ]
机构
[1] Univ Colorado, Anschutz Med Ctr, Aurora, CO 80045 USA
[2] Mt Reg Vet Affairs Med Ctr, Aurora, CO USA
[3] Denver Hlth Hosp Author, Denver, CO USA
[4] Univ Calif San Diego, San Diego, CA 92103 USA
关键词
SUSCEPTIBILITY GENE-MUTATIONS; YOUNG-ONSET; FAMILY-HISTORY; UNITED-STATES; TASK-FORCE; 1ST-DEGREE RELATIVES; MOLECULAR-FEATURES; LYNCH SYNDROME; FOLLOW-UP; ADULTS;
D O I
10.1016/S2468-1253(21)00426-X
中图分类号
R57 [消化系及腹部疾病];
学科分类号
100201 [内科学];
摘要
The incidence of early-onset colorectal cnacer-ie, colorectal cancer diagnosed in patients under the age of 50 years- has been increasing around the world. This Series paper provides a comprehensive review on the topic of early-onset colorectal cancer, including examining the epidemiology of early-onset colorectal cancer around the world, clinical and pathological features, genetic and epigenetic landscapes, and emerging data on the clinical risk factors associated with this malignancy. Evidence-based approaches to prevention and early detection are also presented.
引用
收藏
页码:262 / 274
页数:13
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