High throughput screening methods for asymmetric synthesis

被引：11

作者：

Charbonneau, V ^{[1
]}

Ogilvie, WW ^{[1
]}

机构：

[1] Univ Ottawa, Dept Chem, Ottawa, ON K1N 6N5, Canada

来源：

MINI-REVIEWS IN ORGANIC CHEMISTRY | 2005年 / 2卷 / 04期

关键词：

high throughput screening; combinatorial chemistry; parallel synthesis; reaction screening; asymmetric reaction screening; enantioselective reaction screening;

D O I：

10.2174/157019305774322725

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Combinatorial and high throughput methods have recently been applied to chemical reaction development as it greatly increases the reactivity "space" available to the chemist. Recent focus has been the development of detection methods, particularly those directed towards enantioselectivity. Progress in this area has been reviewed with particular emphasis placed on recent enantioselective methods.

引用

收藏

页码：313 / 332

页数：20

相关论文

共 128 条

[51]

Janes LE, 1998, CHEM-EUR J, V4, P2324, DOI 10.1002/(SICI)1521-3765(19981102)4:11<2324::AID-CHEM2324>3.3.CO

[52]

2-9

[53] Quick E. A fast spectrophotometric method to measure the enantioselectivity of hydrolases [J].

Janes, LE ;

Kazlauskas, RJ .

JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (14) :4560-4561

[54] Fluorescence-based screening of asymmetric acylation catalysts through parallel enantiomer analysis. Identification of a catalyst for tertiary alcohol resolution [J].

Jarvo, ER ;

Evans, CA ;

Copeland, GT ;

Miller, SJ .

JOURNAL OF ORGANIC CHEMISTRY, 2001, 66 (16) :5522-5527

[55]

Kagan H.B., 2007, TOPICS STEREOCHEMIST, V18, P249, DOI 10.1002/9780470147276.ch4

[56] Transition metal-catalyzed addition of amines to acrylic acid derivatives. A high-throughput method for evaluating hydroamination of primary and secondary alkylamines [J].

Kawatsura, M ;

Hartwig, JF .

ORGANOMETALLICS, 2001, 20 (10) :1960-1964

[57] Accelerating lead discovery via advanced screening methodologies [J].

Klein, J ;

Stichert, W ;

Strehlau, W ;

Brenner, A ;

Demuth, D ;

Schunk, SA ;

Hibst, H ;

Storck, S .

CATALYSIS TODAY, 2003, 81 (03) :329-335

[58] Reaction microarrays: A method for rapidly determining the enantiomeric excess of thousands of samples [J].

Korbel, GA ;

Lalic, G ;

Shair, MD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (02) :361-362

[59] Kinetic resolution of terminal epoxides via highly regioselective and enantioselective ring opening with TMSN(3). An efficient, catalytic route to 1,2-amino alcohols [J].

Larrow, JF ;

Schaus, SE ;

Jacobsen, EN .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (31) :7420-7421

[60] Thin layer chromatography for the detection of unexpected reactions in organometallic combinatorial catalysis [J].

Lavastre, O ;

Touzani, R ;

Garbacia, S .

ADVANCED SYNTHESIS & CATALYSIS, 2003, 345 (08) :974-977

← 1 2 3 4 5 6 7 8 9 10 →