Cell-free conversion of 1-deoxy-D-xylulose 5-phosphate and 2-C-methyl-D-erythritol 4-phosphate into β-carotene in higher plants and its inhibition by fosmidomycin

被引：42

作者：

Fellermeier, M

Kis, K

Sagner, S

Maier, U

Bacher, A

Zenk, MH

机构：

[1] Univ Munich, Lehrstuhl Pharmazeut Biol, D-80333 Munich, Germany

[2] Tech Univ Munich, Inst Organ Chem & Biochem, D-85747 Munich, Germany

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 14期

关键词：

1-deoxy-D-xylulose; 5-phosphate; 2-C-methyl-D-erythritol; 4-phosphate; isopentenyl diphosphate; terpenoid biosynthesis;

D O I：

10.1016/S0040-4039(99)00361-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The presence of the deoxyxylulose pathway in chromo- and chloroplasts of various higher plants was demonstrated by the conversion of labelled 1-deoxy-D-xylulose 5-phosphate into beta-carotene and geranylgeraniol, in the presence of ATP. The antibiotic fosmidomycin inhibited the formation of terpenoids from 1-deoxy-D-xylulose 5-phosphate, whereas it did not affect the conversion of 2-C-methyl-D-erythritol 4-phosphate or isopentenyl diphosphate into terpenoids. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2743 / 2746

页数：4

共 16 条

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