A novel aminosteroid is active for proliferation inhibition and differentiation induction of human acute myeloid leukemia HL-60 cells

被引：37

作者：

He, Q ^{[1
]}

Jiang, D ^{[1
]}

机构：

[1] Hunan Med Univ, Res Lab Blood Physiol, Changsha 410078, Peoples R China

来源：

LEUKEMIA RESEARCH | 1999年 / 23卷 / 04期

关键词：

aminosteroid; growth inhibition; differentiation; HL-60; leukemia;

D O I：

10.1016/S0145-2126(98)00160-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A novel aminosteroid, 2 beta-(4'-methyl-1'piperazinyl)-3 alpha,17 beta-dihydroxyl-5 alpha-androstane (HY), was found to inhibit proliferation of HL-60 leukemia cells and induce these cells to differentiate toward macrophage-like cells from the following evidence. (1) It inhibited HL-60 cell proliferation by cell counts, colony counts and MTT assay; (2) It caused morphological changes toward macrophage-like cells after culture for 6 days; (3) It induced NET reduction activity; (4) It induced alpha-naphthyl acetate esterase activity and (5) it induced CD11b and CD14 expression indicated by flow cytometry analysis. There is potential for this novel aminosteroid in the treatment of myeloid leukemia. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：369 / 372

页数：4

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