In childhood acute lymphoblastic leukemia, blasts at different stages of immunophenotypic maturation have stem cell properties

被引：199

作者：

le Viseur, Christoph ^{[2
]}

Hotfilder, Marc ^{[2
]}

Bomken, Simon ^{[1
]}

Wilson, Kerrie ^{[1
]}

Roettgers, Silja ^{[3
]}

Schrauder, Andre ^{[4
]}

Rosemann, Annegret ^{[2
]}

Irving, Julie ^{[1
]}

Stam, Ronald W. ^{[5
]}

Shultz, Leonard D. ^{[6
]}

Harbott, Jochen ^{[3
]}

Juergens, Heribert ^{[2
]}

Schrappe, Martin ^{[4
]}

Pieters, Rob ^{[5
]}

Vormoor, Josef ^{[1
,7
]}

机构：

[1] Univ Newcastle Upon Tyne, No Inst Canc Res, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

[2] Univ Childrens Hosp Munster, Dept Pediat Hematol & Oncol, D-48129 Munster, Germany

[3] Univ Childrens Hosp Giessen, Dept Pediat Hematol & Oncol, D-35385 Giessen, Germany

[4] Univ Med Ctr Schleswig Holstein, Dept Pediat, D-24105 Kiel, Germany

[5] Sophia Childrens Univ Hosp, Univ Med Ctr, Erasmus MC, NL-3015 GJ Rotterdam, Netherlands

[6] Jackson Lab, Bar Harbor, ME 04609 USA

[7] Univ Newcastle Upon Tyne, N E England Stem Cell Inst, Newcastle Upon Tyne NE1 4EP, Tyne & Wear, England

来源：

CANCER CELL | 2008年 / 14卷 / 01期

关键词：

D O I：

10.1016/j.ccr.2008.05.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We examined the leukemic stem cell potential of blasts at different stages of maturation in childhood acute lymphoblastic leukemia (ALL). Human leukemic bone marrow was transplanted intrafemorally into NOD/scid mice. Cells sorted using the B precursor differentiation markers CD19, CD20, and CD34 were isolated from patient samples and engrafted mice before serial transplantation into primary or subsequent (up to quaternary) recipients. Surprisingly, blasts representative of all of the different maturational stages were able to reconstitute and reestablish the complete leukemic phenotype in vivo. Sorted blast populations mirrored normal B precursor cells with transcription of a number of stage-appropriate genes. These observations inform a model for leukemia-propagating stem cells in childhood ALL.

引用

页码：47 / 58

页数：12

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