Response to comment on "tumor growth need not be driven by rare cancer stem cells"

被引：24

作者：

Adams, Jerry M. ^{[1
]}

Kelly, Priscilla N.

Dakic, Aleksandar

Nutt, Stephen L.

Strasser, Andreas

机构：

[1] Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia

[2] Univ Melbourne, Dept Med Biol, Melbourne, Vic 3050, Australia

来源：

SCIENCE | 2007年 / 318卷 / 5857期

关键词：

D O I：

10.1126/science.1149672

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A critical issue for cancer biology and therapy is whether most tumor cells or only rare "cancer stem cells" sustain tumor growth. Although the latter model seems supported by the minute proportion of human leukemia cells that can grow in immunodeficient mice, evidence that more than 10% of cells in many mouse leukemias and lymphomas are transplantable challenges its generality.

引用

页数：2

共 16 条

[1] Prospective identification of tumorigenic breast cancer cells [J].

Al-Hajj, M ;

Wicha, MS ;

Benito-Hernandez, A ;

Morrison, SJ ;

Clarke, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988

[2] Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell [J].

Bonnet, D ;

Dick, JE .

NATURE MEDICINE, 1997, 3 (07) :730-737

[3] A QUANTITATIVE ASSAY FOR NUMBER OF MURINE LYMPHOMA CELLS CAPABLE OF PROLIFERATION IN VIVO [J].

BRUCE, WR ;

VANDERGA.H .

NATURE, 1963, 199 (488) :79-&

[4]

Clarke Michael F, 2006, Cancer Res, V66, P9339, DOI 10.1158/0008-5472.CAN-06-3126

[5] Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia [J].

Deshpande, Aniruddha J. ;

Cusan, Monica ;

Rawat, Vijay P. S. ;

Reuter, Hendrik ;

Krause, Alexandre ;

Pott, Christiane ;

Quintanilla-Martinez, Leticia ;

Kakadia, Purvi ;

Kuchenbauer, Florian ;

Ahmed, Farid ;

Delabesse, Eric ;

Hahn, Meinhard ;

Lichter, Peter ;

Kneba, Michael ;

Hiddemann, Wolfgang ;

Macintyre, Elizabeth ;

Mecucci, Cristina ;

Ludwig, Wolf-Dieter ;

Humphries, R. Keith ;

Bohlander, Stefan K. ;

Feuring-Buske, Michaela ;

Buske, Christian .

CANCER CELL, 2006, 10 (05) :363-374

[6]

Furth J, 1937, AM J CANCER, V31, P276, DOI DOI 10.1158/AJC.1937.276

[7] CRITIQUE OF EVIDENCE FOR ACTIVE HOST DEFENCE AGAINST CANCER, BASED ON PERSONAL STUDIES OF 27 MURINE TUMORS OF SPONTANEOUS ORIGIN [J].

HEWITT, HB ;

BLAKE, ER ;

WALDER, AS .

BRITISH JOURNAL OF CANCER, 1976, 33 (03) :241-259

[8] MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors [J].

Huntly, BJP ;

Shigematsu, H ;

Deguchi, K ;

Lee, BH ;

Mizuno, S ;

Duclos, N ;

Rowan, R ;

Amaral, S ;

Curley, D ;

Williams, IR ;

Akashi, K ;

Gilliland, DG .

CANCER CELL, 2004, 6 (06) :587-596

[9] Tumor growth need not be driven by rare cancer stem cells [J].

Kelly, Priscilla N. ;

Dakic, Aleksandar ;

Adams, Jerry M. ;

Nutt, Stephen L. ;

Strasser, Andreas .

SCIENCE, 2007, 317 (5836) :337-337

[10] Comment on "tumor growth need not be driven by rare cancer stem cells" [J].

Kennedy, James A. ;

Barabe, Frederic ;

Poeppl, Armando G. ;

Wang, Jean C. Y. ;

Dick, John E. .

SCIENCE, 2007, 318 (5857) :1722c

← 1 2 →