Tubulin structure: insights into microtubule properties and functions

被引：181

作者：

Downing, KH ^{[1
]}

Nogales, E ^{[1
]}

机构：

[1] Univ Calif Berkeley, Lawrence Berkeley Lab, Donner Lab, Div Life Sci, Berkeley, CA 94720 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1998年 / 8卷 / 06期

关键词：

D O I：

10.1016/S0959-440X(98)80099-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structure of tubulin has recently been determined by electron crystallography, paving the way for a clearer understanding of the unique properties of tubulin that allow its varied functions within the cell. Some of the ongoing work on tubulin can be interpreted in terms of its structure, which can serve to guide future studies.

引用

页码：785 / 791

页数：7

共 51 条

[31]

Luduena RF, 1998, INT REV CYTOL, V178, P207

[32] Control of the structural stability of the tubulin dimer by one high affinity bound magnesium ion at nucleotide N-site [J].

Menéndez, M ;

Rivas, G ;

Díaz, JF ;

Andreu, JM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (01) :167-176

[33] Structural changes at microtubule ends accompanying GTP hydrolysis:: Information from a slowly hydrolyzable analogue of GTP, guanylyl (α,β)methylenediphosphonate [J].

Müller-Reichert, T ;

Chrétien, D ;

Severin, F ;

Hyman, AA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (07) :3661-3666

[34] Structure of the αβtubulin dimer by electron crystallography [J].

Nogales, E ;

Wolf, SG ;

Downing, KH .

NATURE, 1998, 391 (6663) :199-203

[35] Tubulin and FtsZ form a distinct family of GTPases [J].

Nogales, E ;

Downing, KH ;

Amos, LA ;

Löwe, J .

NATURE STRUCTURAL BIOLOGY, 1998, 5 (06) :451-458

[36] MICROTUBULE DYNAMICS IN-VITRO ARE REGULATED BY THE TUBULIN ISOTYPE COMPOSITION [J].

PANDA, D ;

MILLER, HP ;

BANERJEE, A ;

LUDUENA, RF ;

WILSON, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (24) :11358-11362

[37] Microtubule architecture specified by a beta-tubulin isoform [J].

Raff, EC ;

Fackenthal, JD ;

Hutchens, JA ;

Hoyle, HD ;

Turner, FR .

SCIENCE, 1997, 275 (5296) :70-73

[38] Altered β-tubulin isotype expression in paclitaxel-resistant human prostate carcinoma cells [J].

Ranganathan, S ;

Benetatos, CA ;

Colarusso, PJ ;

Dexter, DW ;

Hudes, GR .

BRITISH JOURNAL OF CANCER, 1998, 77 (04) :562-566

[39]

RAO S, 1994, J BIOL CHEM, V269, P3132

[40] CHARACTERIZATION OF THE TAXOL BINDING-SITE ON THE MICROTUBULE - 2-(M-AZIDOBENZOYL)TAXOL PHOTOLABELS A PEPTIDE (AMINO-ACIDS 217-231) OF BETA-TUBULIN [J].

RAO, S ;

ORR, GA ;

CHAUDHARY, AG ;

KINGSTON, DGI ;

HORWITZ, SB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (35) :20235-20238

← 1 2 3 4 5 6 →