Expression of TNF-α protein in omental and subcutaneous adipose tissue in obesity

被引：22

作者：

Cao, Yan Li ^{[1
]}

Hu, Cui Zhu ^{[2
]}

Meng, Xin ^{[1
]}

Wang, Di Fei ^{[1
]}

Zhang, Jin ^{[1
]}

机构：

[1] China Med Univ, Affiliated Hosp 1, Dept Endocrinol, Shenyang 110001, Peoples R China

[2] China Med Univ, Affiliated Hosp 1, Dept Cardiol, Shenyang 110001, Peoples R China

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2008年 / 79卷 / 02期

关键词：

tumor necrosis factor-alpha; obesity; plasminogen activator inhibitor 1; omentum; vascular diseases;

D O I：

10.1016/j.diabres.2007.08.030

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: During the last several years the role of adipose tissue in contributing to obesity-associated cardiovascular and metabolic risk has gained much attention. Aim: To examine the expression of TNF-alpha protein in omental and subcutaneous adipose tissue in correlation with plasma PAI-1 and other clinical parameters in obesity subjects. Material and methods: Paired biopsies of omental and subcutaneous fat were collected during surgery in 32 obesity subjects. The expression of TNF-alpha protein in omental and subcutaneous fat was quantified by using Western blot method, and correlations with plasma PAI-1, homeostasis model assessment insulin resistance (HOMA-IR) and lipid were investigated. Results: TNF-alpha protein expression was higher in omental than in subcutaneous adipose tissue (P < 0.01). Significant positive linear correlations were found between TNF-a protein in omental adipose tissue and plasma PAI-1 in obesity subjects. TNF-alpha protein in omental fat was positively associated with HOMA-IR, triglycerides and negatively with HDL-cholesterol. Conclusion: TNF-alpha expression in omental adipose tissue could play a key role in contributing to cardiovascular risk in central obesity subjects. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：214 / 219

页数：6

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