Influence of hyaluronic acid on bacterial and fungal species, including clinically relevant opportunistic pathogens

被引：97

作者：

Ardizzoni, Andrea ^{[2
]}

Neglia, Rachele G. ^{[2
]}

Baschieri, Maria C. ^{[2
]}

Cermelli, Claudio ^{[2
]}

Caratozzolo, Manuela ^{[2
]}

Righi, Elena ^{[2
]}

Palmieri, Beniamino ^{[3
]}

Blasi, Elisabetta ^{[1
,4
]}

机构：

[1] Ist Biol 2 Piano, I-41125 Modena, Italy

[2] Univ Modena & Reggio Emilia, Dipartimento Sci Sanita Pubbl, Modena, Italy

[3] Univ Modena & Reggio Emilia, Dipartimento Chirurg Gen, Modena, Italy

[4] Univ Modena & Reggio Emilia, Dipartimento Lab Anat Patol & Med Legale, Modena, Italy

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2011年 / 22卷 / 10期

关键词：

PSEUDOMONAS-AERUGINOSA;

D O I：

10.1007/s10856-011-4408-2

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Hyaluronic acid (HA) has several clinical applications (aesthetic surgery, dermatology, orthopaedics and ophtalmology). Following recent evidence, suggesting antimicrobial and antiviral properties for HA, we investigated its effects on 15 ATCC strains, representative of clinically relevant bacterial and fungal species. The in vitro system employed allowed to assess optical density of broth cultures as a measure of microbial load in a time-dependent manner. The results showed that different microbial species and, sometimes, different strains belonging to the same species, are differently affected by HA. In particular, staphylococci, enterococci, Streptococcus mutans, two Escherichia coli strains, Pseudomonas aeruginosa, Candida glabrata and C. parapsilosis displayed a HA dose-dependent growth inhibition; no HA effects were detected in E. coli ATCC 13768 and C. albicans; S. sanguinis was favoured by the highest HA dose. Therefore, the influence of HA on bacteria and fungi warrants further studies aimed at better establishing its relevance in clinical applications.

引用

页码：2329 / 2338

页数：10

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