Dynamics of plaque formation in Alzheimer's disease

被引：55

作者：

Urbanc, B

Cruz, L

Buldyrev, SV

Havlin, S

Irizarry, MC

Stanley, HE

Hyman, BT

机构：

[1] Boston Univ, Ctr Polymer Studies, Dept Phys, Boston, MA 02215 USA

[2] Gonda Goldschmied Ctr, Ramat Gan, Israel

[3] Bar Ilan Univ, Dept Phys, Ramat Gan, Israel

[4] Massachusetts Gen Hosp, Neurol Serv, Boston, MA 02114 USA

来源：

BIOPHYSICAL JOURNAL | 1999年 / 76卷 / 03期

关键词：

D O I：

10.1016/S0006-3495(99)77295-4

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Plaques that form in the brains of Alzheimer patients are made of deposits of the amyloid-beta peptide. We analyze the time evolution of amyloid-beta deposition in immunostained brain slices from transgenic mice. We find that amyloid-beta deposits appear in clusters whose characteristic size increases from 14 mu m in 8-month-old mice to 22 mu m in 12-month-old mice. We show that the clustering has implications for the biological growth of amyloid-beta by presenting a growth model that accounts for the experimentally observed structure of individual deposits and predicts the formation of clusters of deposits and their time evolution.

引用

页码：1330 / 1334

页数：5

共 20 条

[1] NEUROFIBRILLARY TANGLES BUT NOT SENILE PLAQUES PARALLEL DURATION AND SEVERITY OF ALZHEIMERS-DISEASE [J].

ARRIAGADA, PV ;

GROWDON, JH ;

HEDLEYWHYTE, ET ;

HYMAN, BT .

NEUROLOGY, 1992, 42 (03) :631-639

[2] Alzheimer's disease - The ins and outs of amyloid-beta [J].

Beyreuther, K ;

Masters, CL .

NATURE, 1997, 389 (6652) :677-678

[3] RELEASE OF EXCESS AMYLOID BETA-PROTEIN FROM A MUTANT AMYLOID BETA-PROTEIN PRECURSOR [J].

CAI, XD ;

GOLDE, TE ;

YOUNKIN, SG .

SCIENCE, 1993, 259 (5094) :514-516

[4] Aggregation and disaggregation of senile plaques in Alzheimer disease [J].

Cruz, L ;

Urbanc, B ;

Buldyrev, SV ;

Christie, R ;

GomezIsla, T ;

Havlin, S ;

McNamara, M ;

Stanley, HE ;

Hyman, BT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (14) :7612-7616

[5]

ElKhoury J, 1996, NATURE, V382, P716

[6] ALZHEIMER-TYPE NEUROPATHOLOGY IN TRANSGENIC MICE OVEREXPRESSING V717F BETA-AMYLOID PRECURSOR PROTEIN [J].

GAMES, D ;

ADAMS, D ;

ALESSANDRINI, R ;

BARBOUR, R ;

BERTHELETTE, P ;

BLACKWELL, C ;

CARR, T ;

CLEMENS, J ;

DONALDSON, T ;

GILLESPIE, F ;

GUIDO, T ;

HAGOPIAN, S ;

JOHNSONWOOD, K ;

KHAN, K ;

LEE, M ;

LEIBOWITZ, P ;

LIEBERBURG, I ;

LITTLE, S ;

MASLIAH, E ;

MCCONLOGUE, L ;

MONTOYAZAVALA, M ;

MUCKE, L ;

PAGANINI, L ;

PENNIMAN, E ;

POWER, M ;

SCHENK, D ;

SEUBERT, P ;

SNYDER, B ;

SORIANO, F ;

TAN, H ;

VITALE, J ;

WADSWORTH, S ;

WOLOZIN, B ;

ZHAO, J .

NATURE, 1995, 373 (6514) :523-527

[7] SEGREGATION OF A MISSENSE MUTATION IN THE AMYLOID PRECURSOR PROTEIN GENE WITH FAMILIAL ALZHEIMERS-DISEASE [J].

GOATE, A ;

CHARTIERHARLIN, MC ;

MULLAN, M ;

BROWN, J ;

CRAWFORD, F ;

FIDANI, L ;

GIUFFRA, L ;

HAYNES, A ;

IRVING, N ;

JAMES, L ;

MANT, R ;

NEWTON, P ;

ROOKE, K ;

ROQUES, P ;

TALBOT, C ;

PERICAKVANCE, M ;

ROSES, A ;

WILLIAMSON, R ;

ROSSOR, M ;

OWEN, M ;

HARDY, J .

NATURE, 1991, 349 (6311) :704-706

[8]

Harris T. E., 1989, THEORY BRANCHING PRO

[9] GEOMETRICAL CLUSTER GROWTH-MODELS AND KINETIC GELATION [J].

HERRMANN, HJ .

PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS, 1986, 136 (03) :153-224

[10] QUANTITATIVE-ANALYSIS OF SENILE PLAQUES IN ALZHEIMER-DISEASE - OBSERVATION OF LOG-NORMAL SIZE DISTRIBUTION AND MOLECULAR EPIDEMIOLOGY OF DIFFERENCES ASSOCIATED WITH APOLIPOPROTEIN-E GENOTYPE AND TRISOMY-21 (DOWN-SYNDROME) [J].

HYMAN, BT ;

WEST, HL ;

REBECK, GW ;

BULDYREV, SV ;

MANTEGNA, RN ;

UKLEJA, M ;

HAVLIN, S ;

STANLEY, HE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (08) :3586-3590

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