Antithrombotic therapy in atrial fibrillation: A review of randomized trials with special reference to the stroke prevention in atrial fibrillation II (SPAF II) trial

被引：28

作者：

Shivkumar, K

Jafri, SM

Gheorghiade, M

机构：

[1] HENRY FORD HOSP, DETROIT, MI 48202 USA

[2] NORTHWESTERN UNIV, CHICAGO, IL 60611 USA

来源：

PROGRESS IN CARDIOVASCULAR DISEASES | 1996年 / 38卷 / 04期

关键词：

D O I：

10.1016/S0033-0620(96)80018-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nonvalvular atrial fibrillation is common and is associated with a high risk of systemic embolism. Recently, several large randomized trials have been completed that have established the efficacy of antithrombotic therapy for both primary and secondary prevention of systemic thromboembolism with an acceptable rate of bleeding complications in these patients. This section of clinical trials review summarizes data from all published randomized trials of antithrombotic therapy in atrial fibrillation. The efficacy of aspirin versus warfarin is analyzed. The role of clinical and echocardiographic findings to stratify patients is also highlighted. The Stroke Prevention in Atrial Fibrillation II trial is discussed in detail.

引用

页码：337 / 342

页数：6

共 25 条

[1] ATRIAL-FIBRILLATION AND STROKE - 3 NEW STUDIES, 3 REMAINING QUESTIONS [J].

ALBERS, GW .

ARCHIVES OF INTERNAL MEDICINE, 1994, 154 (13) :1443-1448

[2] PREDICTORS OF THROMBOEMBOLISM IN ATRIAL-FIBRILLATION .1. CLINICAL-FEATURES OF PATIENTS AT RISK [J].

ANDERSON, DC ;

ASINGER, RW ;

NEWBURG, SM ;

FARMER, CC ;

WANG, K ;

BUNDLIE, SR ;

KOLLER, RL ;

JAGIELLA, WM ;

KREHER, S ;

JORGENSEN, CR ;

SHARKEY, SW ;

FLAKER, GC ;

WEBEL, R ;

NOLTE, B ;

STEVENSON, P ;

BYER, J ;

WRIGHT, W ;

CHESEBRO, JH ;

WIEBERS, DO ;

HOLLAND, AE ;

MILLER, DM ;

BARDSLEY, WT ;

LITIN, SC ;

MEISSNER, I ;

ZERBE, DM ;

MCANULTY, JH ;

MARCHANT, C ;

COULL, BM ;

FELDMAN, G ;

HAYWARD, A ;

GANDARA, E ;

MACMILLAN, K ;

BLANK, N ;

LEONARD, AD ;

KANTER, MC ;

ISENSEE, LM ;

QUIROGA, ES ;

PRESTI, CH ;

TEGELER, CH ;

LOGAN, WR ;

HAMILTON, WP ;

GREEN, BJ ;

BACON, RS ;

REDD, RM ;

CADELL, DJ ;

GOMEZ, CR ;

JANOSIK, DL ;

LABOVITZ, AJ ;

KELLEY, RE ;

CHAHINE, R .

ANNALS OF INTERNAL MEDICINE, 1992, 116 (01) :1-5

[3]

ANDERSON DC, 1992, ANN INTERN MED, V116, P6

[4]

[Anonymous], 1993, LANCET, V342, P1255, DOI DOI 10.1016/0140-6736(93)92358-Z

[5] TRANSESOPHAGEAL TWO-DIMENSIONAL ECHOCARDIOGRAPHY FOR THE DETECTION OF LEFT ATRIAL APPENDAGE THROMBUS [J].

ASCHENBERG, W ;

SCHLUTER, M ;

KREMER, P ;

SCHRODER, E ;

SIGLOW, V ;

BLEIFELD, W .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1986, 7 (01) :163-166

[6] LEFT ATRIAL SPONTANEOUS ECHO CONTRAST - A CLINICAL AND ECHOCARDIOGRAPHIC ANALYSIS [J].

BLACK, IW ;

HOPKINS, AP ;

LEE, LCL ;

WALSH, WF ;

JACOBSON, BM .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1991, 18 (02) :398-404

[7] CHARACTERISTICS AND PROGNOSIS OF LONE ATRIAL-FIBRILLATION - 30-YEAR FOLLOW-UP IN THE FRAMINGHAM-STUDY [J].

BRAND, FN ;

ABBOTT, RD ;

KANNEL, WB ;

WOLF, PA .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1985, 254 (24) :3449-3453

[8] CANADIAN ATRIAL-FIBRILLATION ANTICOAGULATION (CAFA) STUDY [J].

CONNOLLY, SJ ;

LAUPACIS, A ;

GENT, M ;

ROBERTS, RS ;

CAIRNS, JA ;

JOYNER, C .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1991, 18 (02) :349-355

[9] WARFARIN IN THE PREVENTION OF STROKE ASSOCIATED WITH NONRHEUMATIC ATRIAL-FIBRILLATION [J].

EZEKOWITZ, MD ;

BRIDGERS, SL ;

JAMES, KE ;

CARLINER, NH ;

COLLING, CL ;

GORNICK, CC ;

KRAUSESTEINRAUF, H ;

KURTZKE, JF ;

NAZARIAN, SM ;

RADFORD, MJ ;

RICKLES, FR ;

SHABETAI, R ;

DEYKIN, D .

NEW ENGLAND JOURNAL OF MEDICINE, 1992, 327 (20) :1406-1412

[10] ACTIVATION OF THE COAGULATION SYSTEM IN WOMEN WITH MITRAL-STENOSIS AND SINUS RHYTHM [J].

JAFRI, SM ;

CACERES, L ;

ROSMAN, HS ;

OZAWA, T ;

MAMMEN, E ;

LESCH, M ;

GOLDSTEIN, S .

AMERICAN JOURNAL OF CARDIOLOGY, 1992, 70 (13) :1217-1219

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